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https://hdl.handle.net/2440/90218
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dc.contributor.author | Verma, A. | - |
dc.contributor.author | Sanders, P. | - |
dc.contributor.author | Champagne, J. | - |
dc.contributor.author | Macle, L. | - |
dc.contributor.author | Nair, G. | - |
dc.contributor.author | Calkins, H. | - |
dc.contributor.author | Wilber, D. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Circulation: Arrhythmia and Electrophysiology, 2014; 7(1):55-62 | - |
dc.identifier.issn | 1941-3149 | - |
dc.identifier.issn | 1941-3084 | - |
dc.identifier.uri | http://hdl.handle.net/2440/90218 | - |
dc.description.abstract | BACKGROUND: This study compared generalized complex fractionated atrial electrograms (CFAE) ablation versus a selective CFAE ablation strategy targeting areas of continuous electric activity. METHODS AND RESULTS: Subjects with symptomatic, persistent/high-burden paroxysmal atrial fibrillation (AF) were enrolled at 6 centers (n=86) and randomized to 1 of 2 arms. For group I, all CFAE regions with an interval confidence level >7 were ablated followed by pulmonary vein isolation (PVI). For group II, only CFAE sites with continuous electric activity were ablated followed by PVI. For PVI, all 4 PV antra were isolated with confirmed entrance block. Subjects were followed for 1 year with a visit, ECG, and 48-hour Holter every 3 months. Symptoms were confirmed by loop recording. The primary end point was freedom from arrhythmia >30 seconds at 1 year. For both group I and II, CFAE ablation prolonged AF cycle length (25±33 versus 23±33 ms; P=0.78) and resulted in similar rates of AF termination (37% versus 28%; P=0.42). Radiofrequency duration during CFAE ablation was significantly less in group II (23±20 versus 38±20 minutes; P=0.002). At 1-year follow-up, freedom from AF/atrial flutter/atrial tachycardia recurrence was significantly higher in group I versus group II after 1 procedure (50% versus 28%; P=0.03). There were also significantly fewer repeat procedures in group I (13% versus 36%; P=0.021). CONCLUSIONS: Continuous electric activity ablation+PVI result in a similar incidence of acute AF termination with significantly less radiofrequency time. However, incidence of repeat procedures and long-term recurrence of AF/atrial flutter/atrial tachycardia are significantly lower using generalized CFAE ablation+PVI. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00926783. | - |
dc.description.statementofresponsibility | Atul Verma, Prashanthan Sanders, Jean Champagne, Laurent Macle, Girish M. Nair, Hugh Calkins, David J. Wilber | - |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams and Wilkins | - |
dc.rights | © 2014 American Heart Association, Inc | - |
dc.source.uri | http://dx.doi.org/10.1161/circep.113.000890 | - |
dc.subject | Ablation; atrial fibrillation; fractionated electrograms; randomized trial | - |
dc.title | Selective complex fractionated atrial electrograms targeting for atrial fibrillation study (SELECT AF): a multicenter, randomized trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1161/CIRCEP.113.000890 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Sanders, P. [0000-0003-3803-8429] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
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