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Type: Journal article
Title: Accuracy of biopsy in subtyping periocular basal cell carcinoma
Author: Sun, M.
Wu, A.
Huilgo, S.
Selva, D.
Citation: Ophthalmic Plastic and Reconstructive Surgery, 2015; 31(6):449-451
Publisher: Lippincott, Williams & Wilkins
Issue Date: 2015
ISSN: 0740-9303
Statement of
Michelle T. Sun, Albert Wu, Shyamala C. Huilgol, and Dinesh Selva
Abstract: PURPOSE: To determine the accuracy of initial biopsy in the diagnosis of basal cell carcinoma (BCC) histologic subtype. METHODS: Retrospective histopathologic review of patients with a diagnosis of primary periocular BCC from 2006 to 2013 inclusive. RESULTS: A total of 174 primary BCCs were identified. BCCs were classified as nodular, superficial, or aggressive (including mixed cases with an aggressive component). Punch biopsies were used in 41% of cases, while the remaining patients underwent shave or incision biopsies. The final histologic subtypes at excision were nodular (59%), superficial (7%), nodular and superficial (7%), and aggressive (51%). The overall concordance between the BCC subtype identified in the biopsy specimen and the subsequent excision specimen was 54%. In total, there were 51 cases (29%) of BCC, which included aggressive subtypes, of which 52% of initial biopsies failed to detect an aggressive component. There were 45 cases (26%) of mixed BCC, and an aggressive histologic subtype was present in 73% of these cases. CONCLUSIONS: The accuracy of initial biopsy for BCC histologic subtype at excision is highest for nodular BCC. For aggressive BCC, biopsy was able to detect the aggressive component in only 48% of cases. This may have implications for choice of treatment modality.
Keywords: Humans; Carcinoma, Basal Cell; Eyelid Neoplasms; Skin Neoplasms; Biopsy; Retrospective Studies; Reproducibility of Results
Rights: Copyright © 2015 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.
RMID: 0030015168
DOI: 10.1097/iop.0000000000000372
Appears in Collections:Opthalmology & Visual Sciences publications

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