Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9039
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Type: Journal article
Title: Differences in fatty acid composition of immature and mature articular cartilage in humans and sheep
Author: Cleland, K.
James, M.
Neumann, M.
Gibson, R.
Cleland, L.
Citation: Lipids, 1995; 30(10):949-953
Publisher: American Oil Chemists' Society
Issue Date: 1995
ISSN: 0024-4201
1558-9307
Statement of
Responsibility: 
Katherine A. Cleland, Michael J. James, Mark A. Neumann, Robert A. Gibson and Leslie G. Cleland
Abstract: C hondrocytes are imbedded in an avascular, highly charged extracellular matrix which could form a barrier to the transfer of dietary essential fatty acids (EFA) to chondrocytes. A study was designed to assess the composition of immature and mature joint cartilage with respect to essential and nonessential fatty acids relevant to EFA deficiency. Cartilage and muscle samples were obtained from human fetus, infant and adult cadavers, and from fetal and mature sheep. Lipid extracts were prepared and the fatty acid composition determined. In human and sheep joint cartilage, linoleic acid (LA; 18∶2n−6) content was lower, and n−9 eicosatrienoic acid (ETrA; 20∶3n−9) and arachidonic acid (AA; 20∶4n−6) were higher in fetuses compared to mature subjects. An intermediate pattern was seen in infant cartilage. n−3 Fatty acids tended to be higher in fetal than in mature cartilage in humans and in sheep. In human muscle (and in other noncartilaginous comparison tissues), similar differences between fetuses and adults were seen in LA and AA, but not in ETrA. In fetal sheep muscle, very low LA, reduced AA and raised ETrA levels compared to mature sheep muscle were seen. However, although the pattern is characteristic of EFA deficiency, the abundance of n−6 EFA in liver and spleen of human fetuses and of n−3 EFA in liver and spleen of fetal sheep suggests that placental transfer of EFA is not likely to be limiting. During fetal development, the metabolism of fatty acids is distinctive and differs between the species. ETrA appears to be a readily measurable component of some tissues at certain stages of development when its presence in tissues does not indicate EFA deficiency.
Keywords: Cartilage, Articular; Muscles; Animals; Sheep; Humans; Arthritis; Fatty Acids; Arachidonic Acid; 8,11,14-Eicosatrienoic Acid; Linoleic Acids; Linoleic Acid; Aging; Reference Values; Adult; Aged; Aged, 80 and over; Middle Aged; Infant; Male
RMID: 0030004828
DOI: 10.1007/BF02537487
Appears in Collections:Medicine publications

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