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|Title:||The national incidence and clinical picture of SLE in children in Australia - a report from the Australian Paediatric Surveillance Unit|
|Citation:||Lupus, 2015; 24(1):66-73|
|F E Mackie, G Kainer, N Adib, C Boros, E J Elliott, R Fahy, J Munro, K Murray, A Rosenberg, B Wainstein, J B Ziegler, D Singh-Grewal|
|Abstract:||OBJECTIVES The objectives of this paper are to prospectively determine the incidence of paediatric systemic lupus erythematosus (pSLE) in Australia as well as describe the demographics, clinical presentation and one-year outcome. STUDY DESIGN Newly diagnosed cases of pSLE were ascertained prospectively from October 2009 to October 2011 through the Australian Paediatric Surveillance Unit (a national monthly surveillance scheme for notification of childhood rare diseases) as well as national subspecialty groups. Questionnaires were sent to notifying physicians at presentation and at one year. RESULTS The annual incidence rate was 0.32 per 105 children aged less than 16 years. The incidence was significantly higher in children of Asian or Australian Aboriginal and Torres Strait Islander parents. Approximately one-third of children underwent a renal biopsy at presentation and 7% required dialysis initially although only one child had end-stage kidney disease (ESKD) at one-year follow-up. CONCLUSION The incidence of pSLE in Australia is comparable to that worldwide with a significantly higher incidence seen in children of Asian and Australian Aboriginal and Torres Strait Islander backgrounds. Renal involvement is common but progression to ESKD, at least in the short term, is rare.|
|Keywords:||Systemic lupus erythematosus; incidence; Australian Aboriginal and Torres Strait Islanders; lupus nephritis|
|Rights:||© The Author(s), 2014.|
|Appears in Collections:||Paediatrics publications|
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