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https://hdl.handle.net/2440/9126
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Type: | Journal article |
Title: | Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects |
Author: | Kong, M.F. Chapman, I. Goble, E. Wishart, J. Wittert, G. Morris, H. Horowitz, M. |
Citation: | Peptides, 1999; 20(-):545-551 |
Publisher: | ELSEVIER SCIENCE INC |
Issue Date: | 1999 |
ISSN: | 0196-9781 1873-5169 |
Abstract: | Oral glucose is a potent stimulant of glucagon-like peptide-1 (GLP-1) secretion. The effect of oral fructose on GLP-1 secretion in humans is unknown. The aims of this study were to determine (i) whether oral fructose stimulates GLP-1 secretion and (ii) the comparative effects of oral glucose and fructose on appetite. On 3 separate days, 8 fasting healthy males received, in single-blind randomized order (i) 75 g glucose, (ii) 75 fructose, or (iii) 75 g glucose followed by 75 g fructose I h later. Venous glucose, insulin and GLP-1 were measured. Appetite was assessed by visual analog questionnaires and intake of a buffet meal. Whereas glucose and fructose both increased plasma glucose, insulin and GLP-1 (P < 0.000)] for all), the response to glucose was much greater (P < 0.005 for all). There was no increase in plasma GLP-1 when fructose was given after glucose. There was no difference in food intake after oral glucose or fructose. We conclude that oral fructose (75 g) stimulates GLP-1 (and insulin) secretion, but the response is less than that to 75 g glucose. These observations suggest that neither GLP-1 nor insulin play a major role in the regulation of satiation. |
Keywords: | Humans Glucagon Insulin Dietary Carbohydrates Fructose Glucose Blood Glucose Peptide Fragments Protein Precursors Hunger Appetite Satiety Response Adult Male Glucagon-Like Peptide 1 |
DOI: | 10.1016/S0196-9781(99)00006-6 |
Published version: | http://dx.doi.org/10.1016/s0196-9781(99)00006-6 |
Appears in Collections: | Aurora harvest Medicine publications |
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