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https://hdl.handle.net/2440/9126
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dc.contributor.author | Kong, M.F. | - |
dc.contributor.author | Chapman, I. | - |
dc.contributor.author | Goble, E. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Wittert, G. | - |
dc.contributor.author | Morris, H. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Peptides, 1999; 20(-):545-551 | - |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.issn | 1873-5169 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9126 | - |
dc.description.abstract | Oral glucose is a potent stimulant of glucagon-like peptide-1 (GLP-1) secretion. The effect of oral fructose on GLP-1 secretion in humans is unknown. The aims of this study were to determine (i) whether oral fructose stimulates GLP-1 secretion and (ii) the comparative effects of oral glucose and fructose on appetite. On 3 separate days, 8 fasting healthy males received, in single-blind randomized order (i) 75 g glucose, (ii) 75 fructose, or (iii) 75 g glucose followed by 75 g fructose I h later. Venous glucose, insulin and GLP-1 were measured. Appetite was assessed by visual analog questionnaires and intake of a buffet meal. Whereas glucose and fructose both increased plasma glucose, insulin and GLP-1 (P < 0.000)] for all), the response to glucose was much greater (P < 0.005 for all). There was no increase in plasma GLP-1 when fructose was given after glucose. There was no difference in food intake after oral glucose or fructose. We conclude that oral fructose (75 g) stimulates GLP-1 (and insulin) secretion, but the response is less than that to 75 g glucose. These observations suggest that neither GLP-1 nor insulin play a major role in the regulation of satiation. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.source.uri | http://dx.doi.org/10.1016/s0196-9781(99)00006-6 | - |
dc.subject | Humans | - |
dc.subject | Glucagon | - |
dc.subject | Insulin | - |
dc.subject | Dietary Carbohydrates | - |
dc.subject | Fructose | - |
dc.subject | Glucose | - |
dc.subject | Blood Glucose | - |
dc.subject | Peptide Fragments | - |
dc.subject | Protein Precursors | - |
dc.subject | Hunger | - |
dc.subject | Appetite | - |
dc.subject | Satiety Response | - |
dc.subject | Adult | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.title | Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0196-9781(99)00006-6 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Wittert, G. [0000-0001-6818-6065] | - |
dc.identifier.orcid | Morris, H. [0000-0002-2745-3750] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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