Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/91459
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Type: Journal article
Title: Serum relaxin in pregnancy
Author: Maclennan, A.
Nicolson, R.
Green, R.
Citation: The Lancet, 1986; 328(8501):241-243
Publisher: Elsevier Science
Issue Date: 1986
ISSN: 0140-6736
1474-547X
Statement of
Responsibility: 
Alastair H. Maclennan, Ruth Nicolson, Roslyn C. Green
Abstract: Serum relaxin immunoactivity was measured by means of a porcine radioimmunoassay in a cross-sectional study of 302 normal singleton pregnancies. Concentrations in the third trimester were lower than in early and mid pregnancy. At term, relaxin levels in patients who went into spontaneous labour within a week of sampling were significantly lower than in those who did not. However, relaxin levels were highest during labour and fell almost to non-pregnant levels by the third postnatal day. Levels in twin pregnancies in the third trimester were higher than those in singleton pregnancies. Serial samples from 4 patients with a history of premature labour showed declining, very low levels in the only patient who subsequently had a preterm delivery. These results are compatible with the proposed roles of relaxin during pregnancy: namely, to maintain myometrial quiescence, facilitate uterine stromal remodelling during uterine growth, and promote cervical ripening at the onset of parturition.
Keywords: Humans; Relaxin; Radioimmunoassay; Postpartum Period; Pregnancy; Labor, Obstetric; Pregnancy, Multiple; Pregnancy Trimester, Third; Female; Obstetric Labor, Premature
Rights: Copyright © 1986 Published by Elsevier Ltd.
RMID: 0030023561
DOI: 10.1016/S0140-6736(86)92068-4
Appears in Collections:Obstetrics and Gynaecology publications

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