Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/9150
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Type: Journal article
Title: The usefulness of a structured questionnaire in the assessment of symptomatic gastresophageal reflux disease
Author: Carlsson, R.
Dent, J.
Bolling-Sternevald, E.
Johnsson, F.
Junghard, O.
Lauritsen, K.
Riley, S.
Lundell, L.
Citation: Scandinavian Journal of Gastroenterology, 1998; 33(10):1023-1029
Publisher: TAYLOR & FRANCIS LTD
Issue Date: 1998
ISSN: 0036-5521
1502-7708
Abstract: <h4>Background</h4>The diagnosis of gastroesophageal reflux disease (GERD) rests primarily on recognition of symptom patterns that are classical for reflux disease, but little attention has been paid to the use of a formal questionnaire for identifying such symptom patterns.<h4>Methods</h4>A self-administered questionnaire was developed which has seven items that focus on the nature of the symptoms and the precipitating, exacerbating, and relieving factors. The diagnostic validity of the questionnaire was tested against endoscopy and 24-h pH monitoring. A further evaluation was undertaken in patients with symptoms suggestive of GERD and in patients with non-ulcer dyspepsia, to identify factors that might predict symptom relief during treatment with omeprazole.<h4>Results</h4>When endoscopic esophageal mucosal breaks and 24-h pH data were used as criteria for the diagnosis of GERD, the questionnaire had a sensitivity of 92% but a very low specificity of 19%. Symptom relief during treatment with omeprazole was predicted by the presence of heartburn, described as 'a burning feeling rising from the stomach or lower chest up towards the neck' (P = 0.004), and 'relief from antacids' (P = 0.02). In non-ulcer dyspepsia a positive response to omeprazole was confined to the subgroup of patients who identified their main discomfort as heartburn as described above.<h4>Conclusion</h4>The present questionnaire using descriptive language usefully identified heartburn in patients presenting with upper abdominal symptoms, and this symptom predicted symptom resolution during treatment with omeprazole.
Keywords: Humans
Gastroesophageal Reflux
Esophagitis, Peptic
Dyspepsia
Heartburn
Omeprazole
Anti-Ulcer Agents
Endoscopy, Digestive System
Gastric Acidity Determination
Monitoring, Ambulatory
Sensitivity and Specificity
Predictive Value of Tests
Surveys and Questionnaires
DOI: 10.1080/003655298750026697
Description (link): http://www.ncbi.nlm.nih.gov/pubmed/9829354
Published version: http://dx.doi.org/10.1080/003655298750026697
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