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Type: Journal article
Title: Panitumumab in the management of patients with KRAS wild-type metastatic colorectal cancer
Author: Hocking, C.
Price, T.
Citation: Therapeutic Advances in Gastroenterology, 2014; 7(1):20-37
Publisher: SAGE Publications
Issue Date: 2014
ISSN: 1756-283X
Statement of
Christopher M. Hocking and Timothy J. Price
Abstract: The past 15 years has seen a marked increase in available therapeutic options for patients with metastatic colorectal cancer resulting in improvements in median survival from 12 to 24 months. One of these new options is panitumumab, which is a fully humanized monoclonal antibody that binds to the epidermal growth factor receptor of tumor cells and inhibits downstream cell signaling with antitumor effects of inhibition of tumor growth, induction of apoptosis and inhibition of angiogenesis. Large randomized clinical trials have demonstrated significant improvements in tumor response rates and progression-free survival when panitumumab is combined with chemotherapy and as monotherapy in chemorefractory metastatic colorectal cancer. Clinical benefit with panitumumab is limited to patients with nonmutated KRAS tumors. Rash is a common toxicity of panitumumab treatment but can potentially be ameliorated with the use of prophylactic strategies. The role of panitumumab in the overall treatment of metastatic colorectal cancer is evolving and future clinical trials will focus on improved patient selection through use of novel predictive biomarkers, and the optimal timing of treatment.
Keywords: colorectal; EGFR; KRAS; panitumumab; review
Rights: © The Author(s) 2013
RMID: 0030021286
DOI: 10.1177/1756283X13498660
Appears in Collections:Medicine publications

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