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Type: Journal article
Title: Natural history of gastro-oesophageal reflux disease diagnosed in general practice
Author: Ruigomez, A.
Garcia Rodriguez, A.
Wallander, M.
Johansson, S.
Graffner, H.
Dent, J.
Citation: Alimentary Pharmacology & Therapeutics, 2004; 20(7):751-760
Publisher: Blackwell Publishing Ltd
Issue Date: 2004
ISSN: 0269-2813
Abstract: Cross-sectional studies indicate that gastro-oesophageal reflux disease symptoms have a prevalence of 10-20% in Western countries and are associated with obesity, smoking, oesophagitis, chest pain and respiratory disease.To determine the natural history of gastro-oesophageal reflux disease presenting in primary care in the UK.Patients with a first diagnosis of gastro-oesophageal reflux disease during 1996 were identified in the UK General Practice Research Database and compared with age- and sex-matched controls. We investigated the incidence of gastro-oesophageal reflux disease, potential risk factors and comorbidities, and relative risk for subsequent oesophageal complications and mortality.The incidence of a gastro-oesophageal reflux disease diagnosis was 4.5 per 1000 person-years (95% confidence interval: 4.4-4.7). Prior use of non-steroidal anti-inflammatory drugs, smoking, excess body weight and gastrointestinal and cardiac conditions were associated with an increased risk of gastro-oesophageal reflux disease diagnosis. Subjects with gastro-oesophageal reflux disease had an increased risk of respiratory problems, chest pain and angina in the year after diagnosis, and had a relative risk of 11.5 (95% confidence interval: 5.9-22.3) of being diagnosed with an oesophageal complication. There was an increase in mortality in the gastro-oesophageal reflux disease cohort only in the year following the diagnosis.Gastro-oesophageal reflux disease is a disease associated with a range of potentially serious oesophageal complications and extra-oesophageal diseases.
Keywords: Humans; Gastroesophageal Reflux; Nitrates; Steroids; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Risk Factors; Cohort Studies; Family Practice; Adolescent; Adult; Aged; Middle Aged; Child; Child, Preschool; Infant; Patient Acceptance of Health Care; Female; Male; United Kingdom
RMID: 0020041792
DOI: 10.1111/j.1365-2036.2004.02169.x
Appears in Collections:Medicine publications

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