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https://hdl.handle.net/2440/9185
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DC Field | Value | Language |
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dc.contributor.author | Ruigomez, A. | - |
dc.contributor.author | Garcia Rodriguez, A. | - |
dc.contributor.author | Wallander, M. | - |
dc.contributor.author | Johansson, S. | - |
dc.contributor.author | Graffner, H. | - |
dc.contributor.author | Dent, J. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Alimentary Pharmacology and Therapeutics, 2004; 20(7):751-760 | - |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.issn | 1365-2036 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9185 | - |
dc.description.abstract | <h4>Background</h4>Cross-sectional studies indicate that gastro-oesophageal reflux disease symptoms have a prevalence of 10-20% in Western countries and are associated with obesity, smoking, oesophagitis, chest pain and respiratory disease.<h4>Aim</h4>To determine the natural history of gastro-oesophageal reflux disease presenting in primary care in the UK.<h4>Methods</h4>Patients with a first diagnosis of gastro-oesophageal reflux disease during 1996 were identified in the UK General Practice Research Database and compared with age- and sex-matched controls. We investigated the incidence of gastro-oesophageal reflux disease, potential risk factors and comorbidities, and relative risk for subsequent oesophageal complications and mortality.<h4>Results</h4>The incidence of a gastro-oesophageal reflux disease diagnosis was 4.5 per 1000 person-years (95% confidence interval: 4.4-4.7). Prior use of non-steroidal anti-inflammatory drugs, smoking, excess body weight and gastrointestinal and cardiac conditions were associated with an increased risk of gastro-oesophageal reflux disease diagnosis. Subjects with gastro-oesophageal reflux disease had an increased risk of respiratory problems, chest pain and angina in the year after diagnosis, and had a relative risk of 11.5 (95% confidence interval: 5.9-22.3) of being diagnosed with an oesophageal complication. There was an increase in mortality in the gastro-oesophageal reflux disease cohort only in the year following the diagnosis.<h4>Conclusions</h4>Gastro-oesophageal reflux disease is a disease associated with a range of potentially serious oesophageal complications and extra-oesophageal diseases. | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1365-2036.2004.02169.x | - |
dc.subject | Humans | - |
dc.subject | Gastroesophageal Reflux | - |
dc.subject | Nitrates | - |
dc.subject | Steroids | - |
dc.subject | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject | Antirheumatic Agents | - |
dc.subject | Risk Factors | - |
dc.subject | Cohort Studies | - |
dc.subject | Family Practice | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Child | - |
dc.subject | Child, Preschool | - |
dc.subject | Infant | - |
dc.subject | Patient Acceptance of Health Care | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | United Kingdom | - |
dc.title | Natural history of gastro-oesophageal reflux disease diagnosed in general practice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1365-2036.2004.02169.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Medicine publications |
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