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https://hdl.handle.net/2440/91916
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Type: | Journal article |
Title: | Antibody and cell-mediated immunity to pertussis 4 years after monovalent acellular pertussis vaccine at birth |
Author: | Wood, N. Marshall, H. White, O. Holt, P. McIntyre, P. |
Citation: | The Pediatric Infectious Disease Journal, 2014; 33(5):511-517 |
Publisher: | Lippincott, Williams & Wilkins |
Issue Date: | 2014 |
ISSN: | 0891-3668 1532-0987 |
Statement of Responsibility: | Nicholas Wood, Helen Marshall, Olivia J. White, Patrick G. Holt, and Peter McIntyre |
Abstract: | Background: In a previous study, we found that monovalent acellular pertussis (aP) vaccine at birth and 1 month achieves higher IgG antibody (Ab) levels to pertussis toxoid (PT), filamentous hemagglutinin (FHA) and pertactin by 8 weeks, when compared with controls. Here, we report antibody and cell-mediated immune responses to 4 years of age. Methods: IgG Ab to PT, filamentous hemagglutinin and pertactin, diphtheria (D) and tetanus (T) was measured in the 3 groups (aP vaccine at birth and 1 month, aP birth only and no aP) at 2 years of age and before and after DTaP-inactivated polio vaccine (DTaP-IPV) at 4 years of age. Cell-mediated immune responses to pertussis vaccine antigens were measured at 2 years of age. Adverse events following DTaP-IPV were recorded. Results: Of 74 subjects, 52 (70%) were available for follow up. Overall, 11 (21%) had detectable PT IgG at 2 years, decreasing to 10% before 4-year-old booster compared with 100% at 8 months of age. After the 4-year booster, pertussis antigen IgG levels were similar, but there was a trend to lower PT IgG levels in birth aP infants (geometric mean concentrations: 28.7 EI.U/mL) compared with controls (geometric mean concentrations: 53.6 EI.U/mL). The cytokine responses to pertussis antigen stimulation were higher in aP recipients at 2 years of age. There was no difference in injection site reactions among groups following the DTaP-IPV booster at 4 years of age. Conclusions: In the longest reported follow-up of infants who received aP vaccine at birth, we found a trend to lower PT IgG antibodies post booster compared with receipt of first dose of aP-containing vaccine at 8 weeks of age. Short- and long-term antibody responses with and without prior maternal pertussis vaccination are crucial for further evaluation of this strategy for preventing severe early pertussis. |
Keywords: | birth; acellular pertussis vaccine; immunogenicity |
Rights: | Copyright © 2014 by Lippincott Williams & Wilkins |
DOI: | 10.1097/INF.0000000000000246 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1016272 |
Published version: | http://dx.doi.org/10.1097/inf.0000000000000246 |
Appears in Collections: | Aurora harvest 2 Paediatrics publications |
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