Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9222
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Type: Journal article
Title: Proximal gastric compliance and perception of distension in type 1 diabetes mellitus: effects of hyperglycemia
Author: Rayner, C.
Verhagen, M.
Hebbard, G.
Di Matteo, A.
Doran, S.
Horowitz, M.
Citation: American Journal of Gastroenterology, 2000; 95(5):1175-1183
Publisher: Blackwell Publishing Ltd
Issue Date: 2000
ISSN: 0002-9270
1572-0241
Statement of
Responsibility: 
Christopher K. Rayner, Marc A.M.T. Verhagen, Geoffrey S. Hebbard, Addolorata C. DiMatteo, Selena M. Doran, and Michael Horowitz
Abstract: OBJECTIVES: Upper GI symptoms and disordered gastric motor function occur frequently in patients with type 1 diabetes mellitus and may be influenced by the blood glucose concentration. The aims of this study were to evaluate proximal gastric compliance and perception of gastric distension during euglycemia and hyperglycemia in unselected patients with type 1 diabetes. METHODS: Ten randomly selected patients with type 1 diabetes were studied. On a single day, isovolumetric and isobaric distensions of the proximal stomach were performed during both euglycemia (blood glucose, 6 mmol/L) and hyperglycemia (15 mmol/L), in randomized order. Sensations of fullness, nausea, and bloating were scored using visual analog scales during each step. Results were compared with those obtained in 10 healthy subjects studied during euglycemia. RESULTS: During euglycemia, perceptions of fullness (p < 0.01), nausea (p < 0.01), and bloating (p < 0.05) were greater during gastric distension in patients with diabetes when compared with healthy controls. In the patients, hyperglycemia increased gastric compliance (p < 0.05) when compared to euglycemia. CONCLUSIONS: In unselected patients with type 1 diabetes 1) the perception of gastric distension during euglycemia is increased compared with healthy controls, and 2) hyperglycemia increases proximal gastric compliance.
Keywords: Stomach; Humans; Diabetes Mellitus, Type 1; Blood Glucose; Random Allocation; Perception; Compliance; Pressure; Adult; Female; Male
RMID: 0001001407
DOI: 10.1111/j.1572-0241.2000.02006.x
Appears in Collections:Medicine publications

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