Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/9234
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Type: Journal article
Title: Nutrient-induced spatial patterning of human duodenal motor function
Author: Andrews, J.
Doran, S.
Hebbard, G.
Malbert, C.
Horowitz, M.
Dent, J.
Citation: American Journal of Physiology: Gastrointestinal and Liver Physiology, 2001; 280(3):G501-G509
Publisher: Amer Physiological Soc
Issue Date: 2001
ISSN: 0193-1857
1522-1547
Statement of
Responsibility: 
Jane M. Andrews, Selena M. Doran, Geoffrey S. Hebbard, Charles H. Malbert, Michael Horowitz, and John Dent
Abstract: The spatiotemporal patterning of duodenal motor function has been evaluated comprehensively for the first time in humans, with a novel 21-lumen manometric assembly. In nine young, healthy volunteers (6 male, 3 female), duodenal motility was recorded during fasting and three 45-min intraduodenal (ID) nutrient infusion periods (Intralipid at 0.25, 0.5, and 1.5 kcal/min). Pressures were recorded along the length of the duodenum with an array of 18 sideholes at 1.5-cm intervals. Pressure patterns were compared for the final 20 min of each of the four periods. Compared with fasting, ID lipid was associated with regional variation in pressure wave (PW) sequences, with fewer proximally and more distally; this was not observed during fasting (P , 0.001). During fasting and all rates of lipid infusion, most (87–90%) PW sequences were short (1.5–4.5 cm), with a small number (2–4%) of 10.5 cm or longer. At all times, antegrade PW sequences occurred more frequently than retrograde sequences over all distances examined (3, 4.5, and .6 cm), and the proportion of antegrade sequences increased with greater PW sequence length (P 5 0.0001). Increasing ID lipid rates appeared to produce dose-related suppression of PW sequences (P , 0.001). The frequency and spatial patterning of human duodenal motor function show substantial variability in response to different nutrient delivery rates. These complex patterns are likely to be involved in duodenal modulation of flow and gastric emptying rate.
Keywords: pressure wave sequences
intralipid
high-resolution manometry
Description: Published abstract used with permission of the copyright owner. Copyright © 2005 by the American Physiological Society
DOI: 10.1152/ajpgi.2001.280.3.g501
Published version: http://ajpgi.physiology.org/cgi/content/abstract/280/3/G501
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