Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9241
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Relationships between spatial patterns of colonic pressure and individual movements of content |
Author: | Cook, I. Furukawa, Y. Panagopoulos, V. Collins, P. Dent, J. |
Citation: | American Journal of Physiology: Gastrointestinal and Liver Physiology, 2000; 278(2 41-2):G329-G341 |
Publisher: | Amer Physiological Soc |
Issue Date: | 2000 |
ISSN: | 0193-1857 1522-1547 |
Statement of Responsibility: | Ian J. Cook, Yoshiyuki Furukawa, Voula Panagopoulos, Peter J. Collins, and John Dent |
Abstract: | The aim of this study was to examine the relationship between colonic pressure waves and movement of content. In 11 healthy subjects, pressures were recorded at 10-cm intervals from cecum to rectum for 32 h. In six subjects, transit was simultaneously measured for 8 h after direct cecal instillation of 1.5 mCi of (99m)Tc sulfur colloid. Thirty-two percent of isotope movements were related to nonpropagating activity and twenty-eight percent to propagating sequences. The extent of isotope movement related to propagating sequences (25.1 +/- 2.1 cm) was greater than that due to nonpropagating activity (12.8 +/- 0.7 cm; P = 0.0001). Propagating sequences originated significantly more frequently (P = 0.004) and propagated further (P = 0.0006) in the proximal compared with the distal colon. Only 36% of propagating sequences were propulsive of content, and compared with nonpropulsive sequences, these propagated further (41 +/- 6 vs. 27 +/- 2 cm; P < 0.05) and had a higher probability of originating proximally (P = 0.0003), a higher pressure wave amplitude (50 +/- 5 vs. 34 +/- 4 mmHg; P = 0.0001), and slower velocity (2.2 +/- 0.3 vs. 3.6 +/- 0.47 cm/s; P = 0.02). We conclude that most movements of colonic content are related to pressure waves. There is marked regional variation in the prevalence, velocity, and extent of propagation of propagating pressure wave sequences, which are an important mechanism for transporting content over long distances. The effectiveness of transport by a propagating sequence is influenced by its site of origin, amplitude, and velocity. |
Keywords: | Cecum Colon Rectum Humans Technetium Tc 99m Sulfur Colloid Radionuclide Imaging Manometry Gastrointestinal Motility Pressure Adolescent Adult Male |
DOI: | 10.1152/ajpgi.2000.278.2.g329 |
Published version: | http://dx.doi.org/10.1152/ajpgi.2000.278.2.g329 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.