Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9271
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Predictors of outcome in patients with oligoarthritis - Results of a protocol of intraarticular corticosteroids to all clinically active joints |
Author: | Green, M. Marzo-Ortega, H. Wakefield, R. Astin, P. Proudman, S. Conaghan, P. Hordon, L. Emery, P. |
Citation: | Arthritis and Rheumatism, 2001; 44(5):1177-1183 |
Publisher: | John Wiley & Sons, Inc., Journals |
Issue Date: | 2001 |
ISSN: | 0004-3591 1529-0131 |
Statement of Responsibility: | Green, Michael ; Marzo‐Ortega, Helena ; Wakefield, Richard J. ; Astin, Paul ; Proudman, Susanna ; Conaghan, Philip G. ; Hordon, Lesley ; Emery, Paul |
Abstract: | <h4>Objective</h4>To determine the outcome and the factors that predict the persistence of synovitis following intraarticular corticosteroid injections in patients with recent-onset oligoarthritis.<h4>Methods</h4>Fifty-one patients with < or =5 joints with synovitis (disease duration < or =12 months) were treated with intraarticular injections of methylprednisolone into all joints with clinical synovitis. Predictors of outcome were sought, with the primary end point a complete response (no synovitis on clinical examination) at 12 weeks.<h4>Results</h4>Patient's and physician's assessments of disease activity, the swollen joint count, and function (by Health Assessment Questionnaire) were all significantly improved at 12 weeks (P < 0.001). Twenty-nine patients (57%) were judged to have had a complete response at 2 weeks. The best predictor of response at 12 and 26 weeks was the presence or absence of synovitis at 2 weeks (P = 0.002 and P = 0.004, respectively). At 52 weeks of followup, nearly 50% of the patients still had evidence of synovitis.<h4>Conclusion</h4>Intraarticular corticosteroids are an effective treatment for early oligoarthritis, but there is still a high level of long-term morbidity. Failure to respond by 2 weeks indicates a high likelihood of persistent disease, and this is relevant when producing management guidelines and selecting patients for studies focusing on early intervention. |
Keywords: | Humans Arthritis, Reactive Synovitis Methylprednisolone Anti-Inflammatory Agents Treatment Outcome Injections, Intra-Articular Follow-Up Studies Predictive Value of Tests Adult Aged Middle Aged Female Male Biomarkers |
Rights: | Copyright © 2001 by the American College of Rheumatology |
DOI: | 10.1002/1529-0131(200105)44:5<1177::AID-ANR201>3.0.CO;2-5 |
Published version: | http://dx.doi.org/10.1002/1529-0131(200105)44:5%3C1177::aid-anr201%3E3.0.co;2-5 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.