Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/92721
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Type: Journal article
Title: Risk stratification with cervical length and fetal fibronectin in women with threatened preterm labor before 34 weeks and not delivering within 7 days
Author: Hermans, F.
Bruijn, M.
Vis, J.
Wilms, F.
Oudijk, M.
Porath, M.
Scheepers, H.
Bloemenkamp, K.
Bax, C.
Cornette, J.
Nij Bijvanck, B.
Franssen, M.
Vandenbussche, F.
Kok, M.
Grobman, W.
Van Der Post, J.
Bossuyt, P.
Opmeer, B.
Mol, B.
Schuit, E.
et al.
Citation: Acta Obstetricia et Gynecologica Scandinavica, 2015; 94(7):715-721
Publisher: Wiley
Issue Date: 2015
ISSN: 1600-0412
1600-0412
Statement of
Responsibility: 
Frederik J.R. Hermans, Merel M.C. Bruijn, Jolande Y. Vis, Femke F. Wilms, Martijn A. Oudijk, Martina M. Porath, Hubertina C.J. Scheepers, Kitty W.M. Bloemenkamp, Caroline J. Bax, Jérôme M.J. Cornette, Bas W.A. Nij Bijvanck, Maureen T.M. Franssen, Frank P.H.A. Vandenbussche, Marjolein Kok, William A. Grobman, Joris A.M. Van Der Post, Patrick M.M. Bossuyt, Brent C. Opmeer, Ben Willem J. Mol, Ewoud Schuit, and Gert-Jan Van Baaren
Abstract: OBJECTIVE: To stratify the risk of spontaneous preterm delivery using cervical length (CL) and fetal fibronectin (fFN) in women with threatened preterm labor who remained pregnant after 7 days. DESIGN: Prospective observational study. SETTING: Nationwide cohort of women with threatened preterm labor from the Netherlands. POPULATION: Women with threatened preterm labor between 24 and 34 weeks with a valid CL and fFN measurement and remaining pregnant 7 days after admission. METHODS: Kaplan-Meier and Cox proportional hazards models were used to estimate cumulative percentages and hazard ratios (HR) for spontaneous delivery. MAIN OUTCOME MEASURES: Spontaneous delivery between 7 and 14 days after initial presentation and spontaneous preterm delivery before 34 weeks. RESULTS: The risk of delivery between 7 and 14 days was significantly increased for women with a CL < 15 mm or a CL ≥15 to <30 mm and a positive fFN, compared with women with a CL ≥30 mm: HR 22.3 [95% confidence interval (CI) 2.6-191] and 14 (95% CI 1.8-118), respectively. For spontaneous preterm delivery before 34 weeks the risk was increased for women with a CL < 15 mm [HR 6.3 (95% CI 2.6-15)] or with a CL ≥15 to <30 mm with either positive fFN [HR 3.6 (95% CI 1.5-8.7)] or negative fFN [HR 3.0 (95% CI 1.2-7.1)] compared with women with a CL ≥ 30 mm. CONCLUSIONS: In women remaining pregnant 7 days after threatened preterm labor, CL and fFN results can be used in risk stratification for spontaneous delivery.
Keywords: Threatened preterm labor; fetal fibronectin; cervical length; pregnancy complications; risk; prediction; spontaneous preterm delivery
Rights: © 2015 Nordic Federation of Societies of Obstetrics and Gynecology
RMID: 0030027338
DOI: 10.1111/aogs.12643
Appears in Collections:Paediatrics publications

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