Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/92828
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Type: | Journal article |
Title: | FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis |
Author: | Tan, B. Anaka, M. Deb, S. Freyer, C. Ebert, L. Chueh, A. Al-Obaidi, S. Behren, A. Jayachandran, A. Cebon, J. Chen, W. Mariadason, J. |
Citation: | Oncotarget, 2014; 5(1):264-276 |
Publisher: | Impact Journals |
Issue Date: | 2014 |
ISSN: | 1949-2553 1949-2553 |
Statement of Responsibility: | BeeShin Tan, Matthew Anaka, Siddhartha Deb, Claudia Freyer, Lisa M. Ebert, Anderly C. Chueh, Sheren Al-Obaidi, Andreas Behren, Aparna Jayachandran, Jonathan Cebon, Weisan Chen and John M. Mariadason |
Abstract: | The Forkhead box P3 (FOXP3) transcription factor is the key driver of regulatory T cell (Treg cells) differentiation and immunosuppressive function. In addition, FOXP3 has been reported to be expressed in many tumors, including melanoma. However, its role in tumorigenesis is conflicting, with both tumor suppressive and tumor promoting functions described. The aim of the current study was to characterize the expression and function of FOXP3 in melanoma. FOXP3 expression was detected by immunohistochemistry (IHC) in 12% (18/146) of stage III and IV melanomas. However expression was confined to fewer than 1% of cells in these tumors. Stable over-expression of FOXP3 in the SK-MEL-28 melanoma cell line reduced cell proliferation and clonogenicity in vitro, and reduced xenograft growth in vivo. FOXP3 over-expression also increased pigmentation and the rate of apoptosis of SK-MEL-28 cells. Based on its infrequent expression in human melanoma, and its growth inhibitory and pro-apoptotic effect in over-expressing melanoma cells, we conclude that FOXP3 is not likely to be a key tumor suppressor or promoter in melanoma. |
Keywords: | FOXP3; melanoma; proliferation; apoptosis |
Rights: | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.18632/oncotarget.1600 |
Grant ID: | http://purl.org/au-research/grants/arc/FT0992234 http://purl.org/au-research/grants/nhmrc/603104 http://purl.org/au-research/grants/nhmrc/487905 http://purl.org/au-research/grants/nhmrc/433608 |
Published version: | http://dx.doi.org/10.18632/oncotarget.1600 |
Appears in Collections: | Aurora harvest 7 Pathology publications |
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hdl_92828.pdf | Published version | 3.4 MB | Adobe PDF | View/Open |
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