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https://hdl.handle.net/2440/92975
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Type: | Journal article |
Title: | Homocysteinemia after hypertensive pregnancy disorders at term |
Author: | Visser, S. Hermes, W. Blom, H. Heijboer, A. Franx, A. Van Pampus, M. Bloemenkamp, K. Koopmans, C. Mol, B. De Groot, C. |
Citation: | Journal of Women's Health, 2015; 24(6):524-529 |
Publisher: | Mary Ann Liebert |
Issue Date: | 2015 |
ISSN: | 1931-843X 1931-843X |
Statement of Responsibility: | Visser Sanne, Hermes Wietske, Blom Henk J., Heijboer Annemieke C., Franx Arie, Van Pampus Maria G., Bloemenkamp Kitty W.M., Koopmans Corine, Mol Ben Willem J., and De Groot Christianne J.M |
Abstract: | Background: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascular risk factors, such as lipid profiles and glucose, in women with a history of hypertensive pregnancy disorders. Homocysteine is a sensitive indicator of increased risk but data on homocysteine levels in women with a history of hypertensive pregnancy disorders are inconsistent. Design: This cohort study included 279 women with a history of hypertensive pregnancy disorders at term and 85 women with a history of uncomplicated pregnancies who participated in the Hypitat Risk Assessment Study (HyRAS). Methods: Blood samples for total homocysteine determination were taken 2.5 years postpartum. Homocysteine levels were determined in plasma using an immunoassay. Results: Women with a history of hypertensive pregnancy disorders had significant higher median homo- cysteine levels (10.66 l mol/L) 2.5 years postpartum compared with women with a history uncomplicated pregnancies (9.82 l mol/L; p = 0.002). Women with a history of hypertensive pregnancy disorders had a higher risk of having a homocysteine level in the highest quartile (odds ratio 3.4, 95% confidence interval 1.5–7.6). Conclusion: At 2.5 years postpartum, women with a history hypertensive pregnancy disorders had higher homocysteine levels than women who had uncomplicated pregnancies. Although higher homocysteine levels might be a potential link between a history of hypertensive pregnancy disorders and increased cardiovascular disease risk later in life, the clinical implications remain an area for future research. |
Keywords: | Humans Hypertension, Pregnancy-Induced Hyperhomocysteinemia Homocysteine Linear Models Logistic Models Risk Factors Case-Control Studies Longitudinal Studies Follow-Up Studies Prospective Studies Pregnancy Time Factors Adult Aged Middle Aged Female Biomarkers |
Rights: | © Mary Ann Liebert, Inc |
DOI: | 10.1089/jwh.2015.5201 |
Published version: | http://dx.doi.org/10.1089/jwh.2015.5201 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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