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Type: Journal article
Title: Inappropriate antidiuretic hormone secretion, abdominal pain and disseminated varicella-zoster virus infection: an unusual triad in a patient 6 months post mini-allogeneic peripheral stem cell transplant for chronic myeloid leukemia
Author: Szabo, F.
Horvath, N.
Seimon, S.
Hughes, T.
Citation: Bone Marrow Transplantation, 2000; 26(2):231-233
Publisher: Nature Publishing Group
Issue Date: 2000
ISSN: 0268-3369
Abstract: Severe abdominal pain followed by inappropriate antidiuretic hormone secretion (SIADH) preceding by several days the skin manifestation of varicella-zoster virus (VZV) infection in an immunocompromised patient is described. This is a rare presentation of a severe infection described previously only once in a chronic myeloid leukemia (CML) patient 5 months post allo-BMT during immunosuppressive treatment with cyclosporin A. This is the first case described in the setting of non-myeloablative preparation with fludarabine and melphalan and followed by donor leukocyte infusion (DLI) 2 and 4 months post allo-BMT. The influence of these factors on development of VZV virus infection is discussed. We also highlight the high incidence and high mortality in VZV infection in immunocompromised patients as well as the frequent atypical presentation.
Keywords: Humans; Herpesvirus 3, Human; Chickenpox; Herpes Zoster; Inappropriate ADH Syndrome; Abdominal Pain; Leukocyte Transfusion; Hematopoietic Stem Cell Transplantation; Transplantation, Homologous; Immunocompromised Host; Middle Aged; Male; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
RMID: 0001001266
DOI: 10.1038/sj.bmt.1702486
Appears in Collections:Medicine publications

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