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Type: Journal article
Title: A novel BCR-ABL transcript (e8a2) with the insertion of an inverted sequence of ABL intron 1b in a patient with Philadelphia-positive chronic myeloid leukaemia
Author: Branford, S.
Rudzi, Z.
Hughes, T.
Citation: British Journal of Haematology, 2000; 109(3):635-637
Publisher: Blackwell Publishing Ltd
Issue Date: 2000
ISSN: 0007-1048
Abstract: An atypical BCR-ABL transcript in a patient with Philadelphia (Ph)-positive chronic myeloid leukaemia (CML) was detected using a long polymerase chain reaction technique. Sequence analysis revealed a joining of BCR exon e8 and ABL exon a2, with a 55-base pair (bp) insert of an inverted sequence of ABL intron 1b between them, giving rise to an in frame e8a2 BCR-ABL transcript. This is the first report of a BCR-ABL transcript with the insertion of an inverted sequence. The long PCR technique is a useful screen for atypical BCR-ABL transcripts not detected by standard techniques.
Keywords: Humans; Fusion Proteins, bcr-abl; Electrophoresis, Agar Gel; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Exons; Middle Aged; Male; Artificial Gene Fusion; Leukemia, Myelogenous, Chronic, BCR-ABL Positive
RMID: 0001001267
DOI: 10.1046/j.1365-2141.2000.02042.x
Appears in Collections:Medicine publications

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