Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/93404
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles |
Author: | Valencia, P. Pridgen, E. Perea, B. Gadde, S. Sweeney, C. Kantoff, P. Bander, N. Lippard, S. Langer, R. Karnik, R. Farokhzad, O. |
Citation: | Nanomedicine, 2013; 8(5):687-698 |
Publisher: | Future Medicine |
Issue Date: | 2013 |
ISSN: | 1743-5889 1748-6963 |
Statement of Responsibility: | Pedro M Valencia, Eric M Pridgen, Brian Perea, Suresh Gadde, Christopher Sweeney, Philip W Kantoff, Neil H Bander, Stephen J Lippard, Robert Langer, Rohit Karnik, Omid C Farokhzad |
Abstract: | AIM: Two unexplored aspects for irinotecan and cisplatin (I&C) combination chemotherapy are: actively targeting both drugs to a specific diseased cell type, and delivering both drugs on the same vehicle to ensure their synchronized entry into the cell at a well-defined ratio. In this work, the authors report the use of targeted polymeric nanoparticles (NPs) to coencapsulate and deliver I&C to cancer cells expressing the prostate-specific membrane antigen. MATERIALS & METHODS: Targeted NPs were prepared in a single step by mixing four different precursors inside microfluidic devices. RESULTS: I&C were encapsulated in 55-nm NPs and showed an eightfold increase in internalization by prostate-specific membrane antigen-expressing LNCaP cells compared with nontargeted NPs. NPs coencapsulating both drugs exhibited strong synergism in LNCaP cells with a combination index of 0.2. CONCLUSION: The strategy of coencapsulating both I&C in a single NP targeted to a specific cell type could potentially be used to treat different types of cancer. |
Keywords: | cisplatin combination chemotherapy irinotecan nanoparticle PSMA |
Rights: | Copyright status unknown |
DOI: | 10.2217/nnm.12.134 |
Published version: | http://dx.doi.org/10.2217/nnm.12.134 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.