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Type: Conference item
Title: The fatty-acid composition of brain, retina and erythrocytes in breast and formula-fed infants
Author: Makrides, M.
Neumann, M.
Byard, R.
Simmer, K.
Gibson, R.
Citation: Pediatric Research, 1995, vol.37, iss.4, pp.A127-A127
Publisher: Williams & Wilkins
Issue Date: 1995
ISSN: 0031-3998
Conference Name: The American Pediatric Society and The Society for Pediatric Research Annual Meeting (7 May 1995 - 11 May 1995 : San Diego, California)
Statement of
Maria Makrides, Mark Neumann, Roger Byard, Karen Simmer, Robert Gibson
Abstract: Breast-fed infants score better on visual and developmental tests than do formula-fed infants and this has been related to higher concentrations of erythrocyte docosahexaenoic acid (DHA, 22:6 omega 3). This prompted an investigation into the relationship between brain, retina, and erythrocyte fatty acids and diet in infancy. Total lipids of erythrocytes, retina, and brain cortex from 35 term infants were analyzed by capillary gas chromatography. Breast-fed infants had a greater proportion of DHA in their erythrocytes and brain cortex relative to those fed formula (P < 0.005) but differences were not observed in retina. Cortex DHA increased in breast-fed (but not formula-fed) infants with age (r2 = 0.72, P < 0.01, n = 15), largely an effect of length of feeding (r2 = 0.62, P < 0.01, n = 35). There was an association between age at death and erythrocyte DHA with cortex DHA (r2 = 0.50, P < 0.01). In contrast, accretion of cortex arachidonic acid was dependent on age but not diet. The higher concentration of DHA in brains of breast-fed infants may explain the improved neurodevelopment reported in breast-fed compared with formula-fed infants.
Keywords: Cerebral Cortex
alpha-Linolenic Acid
Docosahexaenoic Acids
Fatty Acids, Unsaturated
Arachidonic Acid
Linoleic Acids
Linoleic Acid
Bottle Feeding
Regression Analysis
Breast Feeding
Infant Food
Infant, Newborn
Rights: Copyright status unknown
DOI: 10.1093/ajcn/60.2.189
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