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|Title:||Successful salvage of RAEB/AML relapsing early post allograft with FLAG-Ida conditioned mini-allograft: a report of two cases|
|Citation:||International Journal of Laboratory Hematology (Print Edition), 2001; 23(2):135-138|
|Publisher:||Blackwell Publishing Ltd|
|C.H. Hui, P. Bardy, T. Hughes, N. Horvath, L.B. To|
|Abstract:||Management options are often limited for patients with AML or high grade myelodysplasia (MDS) relapsing within a year of allogeneic transplantation. We report, in two such patients, the use of re-induction with FLAG-Ida chemotherapy, followed by the infusion of GCSF-mobilized blood stem cells from the same HLA-matched donor. Both patients achieved durable complete remissions with good quality of life and longer disease-free survival than after the first myeloablative allografts. This mini-allograft approach offers a practical, well-tolerated salvage and a potentially curative treatment for relapsed AML/high grade MDS patients failing a first conventional myeloablative allogeneic transplants.|
|Keywords:||Humans; Anemia, Refractory, with Excess of Blasts; Recurrence; Idarubicin; Filgrastim; Granulocyte Colony-Stimulating Factor; Recombinant Proteins; Cytarabine; Vidarabine; Antineoplastic Combined Chemotherapy Protocols; Salvage Therapy; Hematopoietic Stem Cell Transplantation; Transplantation, Homologous; Middle Aged; Female; Leukemia, Myeloid, Acute|
|Description:||The definitive version may be found at www.wiley.com|
|Provenance:||Published Online: 20 Dec 2001|
|Rights:||Copyright © 2001 Blackwell Science Limited|
|Appears in Collections:||Medicine publications|
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