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dc.contributor.authorKhanna, D.en
dc.contributor.authorMittoo, S.en
dc.contributor.authorAggarwal, R.en
dc.contributor.authorProudman, S.en
dc.contributor.authorDalbeth, N.en
dc.contributor.authorMatteson, E.en
dc.contributor.authorBrown, K.en
dc.contributor.authorFlaherty, K.en
dc.contributor.authorWells, A.en
dc.contributor.authorSeibold, J.en
dc.contributor.authorStrand, V.en
dc.identifier.citationThe Journal of rheumatology, 2015; 42(11):2168-2171en
dc.description.abstractOBJECTIVE: Interstitial lung disease (ILD) is common in connective tissue disease (CTD) and is the leading cause of mortality. Investigators have used certain outcome measures in randomized controlled trials (RCT) in CTD-ILD, but the lack of a systematically developed, CTD-specific index that captures all measures relevant and meaningful to patients with CTD-ILD has left a large and conspicuous gap in CTD-ILD research. METHODS: The CTD-ILD working group, under the aegis of the Outcome Measures in Rheumatology (OMERACT) initiative, has completed a consensus group exercise to reach harmony on core domains and items for inclusion in RCT in CTD-ILD. During the OMERACT 12 meeting, consensus was sought on domains and core items for inclusion in RCT. In addition, consensus was pursued on a definition of response in RCT. Consensus was defined as ≥ 75% agreement among the participants. RESULTS: OMERACT 12 participants endorsed the domains with minimal modifications. Clinically meaningful progression for CTD-ILD was proposed as ≥ 10% relative decline in forced vital capacity (FVC) or ≥ 5% to < 10% relative decline in FVC and ≥ 15% relative decline in DLCO. CONCLUSION: There is consensus on domains for inclusion in RCT in CTD-ILD and on a definition of clinically meaningful progression. Data-driven approaches to validate these results in different cohorts and RCT are needed.en
dc.description.statementofresponsibilityDinesh Khanna, Shikha Mittoo, Rohit Aggarwal, Susanna M. Proudman, Nicola Dalbeth, Eric L. Matteson, Kevin Brown, Kevin Flaherty, Athol U. Wells, James R. Seibold, and Vibeke Stranden
dc.publisherJournal of Rheumatology Publishingen
dc.rightsCopyright © 2015. All rights reserved.en
dc.subjectHumans; Lung Diseases, Interstitial; Connective Tissue Diseases; Severity of Illness Index; Incidence; Survival Analysis; Follow-Up Studies; Comorbidity; Adult; Aged; Middle Aged; Societies, Medical; Disease Management; Female; Male; Consensus Development Conferences as Topic; Randomized Controlled Trials as Topic; Outcome Assessment, Health Careen
dc.titleConnective Tissue Disease-associated Interstitial Lung Diseases (CTD-ILD) - report from OMERACT CTD-ILD Working Groupen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidProudman, S. [0000-0002-3046-9884]en
Appears in Collections:Medicine publications

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