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https://hdl.handle.net/2440/9444
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dc.contributor.author | Noakes, M. | - |
dc.contributor.author | Clifton, P. | - |
dc.contributor.author | Doornbos, A. | - |
dc.contributor.author | Trautwein, E. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | European Journal of Nutrition, 2004; 44(4):214-222 | - |
dc.identifier.issn | 1436-6207 | - |
dc.identifier.issn | 1436-6215 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9444 | - |
dc.description.abstract | <h4>Background</h4>The cholesterol-lowering efficacy of plant sterol esters (PSteE) or stanol esters (PStaE) in regular- and low-fat spreads has been consistently demonstrated, while their effectiveness in a low-fat, aqueous food carrier such as milk and yoghurt is less well established.<h4>Aim of the study</h4>Two studies were carried out to assess the cholesterol-lowering effect of PSteE-enriched low-fat milk and PSteE- and PStaE-enriched low-fat yoghurt in modestly hypercholesterolemic subjects (total cholesterol between 5-7.5 mmol/l).<h4>Methods</h4>Study one was a single blind crossover design with 4 phases of 3-week interventions. Subjects consumed 300 ml/d of placebo or PSteE-milk (2.0 g plant sterols/d) alone or combined with 25 g/d of placebo or PSteE-spread. Study two was a fully randomised, double blind crossover design with 3 phases of 3-week interventions. Subjects consumed 2 portions (150 g tubs each) of placebo, PSteE-yoghurt (1.8 g plant sterols/d) or PStaE-yoghurt (1.7 g plant stanols/d). In study one 39 subjects (21 men and 18 women) and in study two 40 subjects (17 men and 23 women) completed the dietary intervention.<h4>Results</h4>In study one, PSteE-milk and PSteE-spread were equally efficacious in lowering total and LDL-cholesterol as compared to placebo by 6-8% and 8-10%, respectively. No significant additional cholesterol-lowering was observed with the combination of PSteE-milk and PSteE-spread (4 g plant sterols/d). PSteE-enriched milk and the combination of PSteE-enriched milk plus spread both lowered lipid-adjusted serum beta-carotene concentrations by 10-14% (P < 0.02),while the PSteE-rich spread alone did not significantly alter serum beta-carotene levels. In study two, the PSteE- and PStaE-enriched yoghurts reduced LDL-cholesterol significantly compared to placebo by 0.27 +/- 0.05 mmol/l (6%) and 0.23 +/- 0.05 mmol/l (5%), respectively. In both studies, there was no effect on HDL-cholesterol and triacylglycerol concentrations.<h4>Conclusion</h4>Plant sterols in the form of their esters when provided in lowfat milk and yoghurt are effective in lowering total and LDL-cholesterol. | - |
dc.language.iso | en | - |
dc.publisher | Dr Dietrich Steinkopff Verlag | - |
dc.source.uri | http://dx.doi.org/10.1007/s00394-004-0513-z | - |
dc.subject | Milk | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Hypercholesterolemia | - |
dc.subject | Esters | - |
dc.subject | Carotenoids | - |
dc.subject | Cholesterol | - |
dc.subject | Sitosterols | - |
dc.subject | Phytosterols | - |
dc.subject | Lipoproteins | - |
dc.subject | Diet, Fat-Restricted | - |
dc.subject | Yogurt | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Diet Records | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Cholesterol, LDL | - |
dc.subject | Cholesterol, HDL | - |
dc.subject | Surveys and Questionnaires | - |
dc.title | Plant sterol ester-enriched milkand yoghurt effectively reduceserum cholesterol in modestlyhypercholesterolemic subjects | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s00394-004-0513-z | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Clifton, P. [0000-0002-6411-626X] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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