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https://hdl.handle.net/2440/94718
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Type: | Journal article |
Title: | Serum levels of human MIC-1/GDF15 vary in a diurnal pattern, do not display a profile suggestive of a satiety factor and are related to BMI |
Author: | Tsai, V. Macia, L. Feinle-Bisset, C. Manandhar, R. Astrup, A. Raben, A. Lorenzen, J. Schmidt, P. Wiklund, F. Pedersen, N. Campbell, L. Kriketos, A. Xu, A. Zhou, P. Jia, W. Curmi, P. Angstmann, C. Lee-Ng, K. Zhang, H. Marquis, C. et al. |
Citation: | PLoS One, 2015; 10(7):e0133362-1-e0133362-15 |
Publisher: | Public Library of Science |
Issue Date: | 2015 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Young, M. |
Statement of Responsibility: | Vicky Wang-Wei Tsai ... Christine Feinle-Bisset ... et al. |
Abstract: | The TGF-b superfamily cytokine MIC-1/GDF15 circulates in the blood of healthy humans. Its levels rise substantially in cancer and other diseases and this may sometimes lead to development of an anorexia/cachexia syndrome. This is mediated by a direct action of MIC-1/GDF15 on feeding centres in the hypothalamus and brainstem. More recent studies in germline gene deleted mice also suggest that this cytokine may play a role in physiological regulation of energy homeostasis. To further characterize the role of MIC-1/GDF15 in physiological regulation of energy homeostasis in man, we have examined diurnal and food associated variation in serum levels and whether variation in circulating levels relate to BMI in human monozygotic twin pairs. We found that the within twin pair differences in serum MIC-1/GDF15 levels were significantly correlated with within twin pair differences in BMI, suggesting a role for MIC-1/GDF15 in the regulation of energy balance in man. MIC-1/GDF15 serum levels altered slightly in response to a meal, but comparison with variation its serum levels over a 24 hour period suggested that these changes are likely to be due to bimodal diurnal variation which can alter serum MIC-1/GDF15 levels by about plus or minus 10% from the mesor. The lack of a rapid and substantial postprandial increase in MIC-1/GDF15 serum levels suggests that MIC1/GDF15 is unlikely to act as a satiety factor. Taken together, our findings suggest that MIC-1/GDF15 may be a physiological regulator of energy homeostasis in man, most probably due to actions on long-term regulation of energy homeostasis. |
Keywords: | Humans Cholecystokinin Body Mass Index Satiation Energy Metabolism Circadian Rhythm Twins Postprandial Period Adult Aged Aged, 80 and over Middle Aged Female Male Glucagon-Like Peptide 1 Growth Differentiation Factor 15 Young Adult |
Rights: | © 2015 Tsai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0133362 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1371/journal.pone.0133362 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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hdl_94718.pdf | Published version | 1.22 MB | Adobe PDF | View/Open |
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