Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Oxytocin receptor genotype modulates ventral striatal activity to social cues and response to stressful life events|
|Citation:||Biological Psychiatry, 2014; 76(5):367-376|
|Eva Loth ... David Stacey ... et. al.|
|Abstract:||Background: Common variants in the oxytocin receptor gene (OXTR) have been shown to influence social and affective behavior and to moderate the effect of adverse experiences on risk for social-affective problems. However, the intermediate neurobiological mechanisms are not fully understood. Although human functional neuroimaging studies have reported that oxytocin effects on social behavior and emotional states are mediated by amygdala function, animal models indicate that oxytocin receptors in the ventral striatum (VS) modulate sensitivity to social reinforcers. This study aimed to comprehensively investigate OXTR-dependent brain mechanisms associated with social-affective problems. Methods: In a sample of 1445 adolescents we tested the effect of 23-tagging single nucleotide polymorphisms across the OXTR region and stressful life events (SLEs) on functional magnetic resonance imaging blood oxygen level–dependent activity in the VS and amygdala to animated angry faces. Single nucleotide polymorphisms for which gene-wide significant effects on brain function were found were then carried forward to examine associations with social-affective problems. Results: A gene-wide significant effect of rs237915 showed that adolescents with minor CC-genotype had significantly lower VS activity than CT/TT-carriers. Significant or nominally significant gene x environment effects on emotional problems (in girls) and peer problems (in boys) revealed a strong increase in clinical symptoms as a function of SLEs in CT/TT-carriers but not CC-homozygotes. However, in low-SLE environments, CC-homozygotes had more emotional problems (girls) and peer problems (boys). Moreover, among CChomozygotes, reduced VS activity was related to more peer problems. Conclusions: These findings suggest that a common OXTR-variant affects brain responsiveness to negative social cues and that in “riskcarriers” reduced sensitivity is simultaneously associated with more social-affective problems in “favorable environments” and greater resilience against stressful experiences.|
|Keywords:||Amygdala; functional magnetic resonance imaging; genetics; oxytocin; social behavior; ventral striatum|
|Rights:||© 2014 Society of Biological Psychiatry|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.