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Type: Journal article
Title: Genetic structure and antimicrobial resistance of Escherichia coli and cryptic clades in birds with diverse human associations
Author: Blyton, M.
Pi, H.
Vangchhia, B.
Abraham, S.
Trott, D.
Johnson, J.
Gordon, D.
Citation: Applied and Environmental Microbiology, 2015; 81(15):5123-5133
Publisher: American Society for Microbiology
Issue Date: 2015
ISSN: 0099-2240
Editor: Griffiths, M.
Statement of
Michaela D. J. Blyton, Hongfei Pi, Belinda Vangchhia, Sam Abraham, Darren J. Trott, James R. Johnson, David M. Gordon
Abstract: The manner and extent to which birds associate with humans may influence the genetic attributes and antimicrobial resistance of their commensal Escherichia communities through strain transmission and altered selection pressures. In this study, we determined whether the distribution of the different Escherichia coli phylogenetic groups and cryptic clades, the occurrence of 49 virulence associated genes, and/or the prevalence of resistance to 12 antimicrobials differed between four groups of birds from Australia with contrasting types of human association. We found that birds sampled in suburban and wilderness areas had similar Escherichia communities. The Escherichia communities of backyard domestic poultry were phylogenetically distinct from the Escherichia communities sourced from all other birds, with a large proportion (46%) of poultry strains belonging to phylogenetic group A and a significant minority (17%) belonging to the cryptic clades. Wild birds sampled from veterinary and wildlife rehabilitation centers (in-care birds) carried Escherichia isolates that possessed particular virulence-associated genes more often than Escherichia isolates from birds sampled in suburban and wilderness areas. The Escherichia isolates from both the backyard poultry and in-care birds were more likely to be multidrug resistant than the Escherichia isolates from wild birds. We also detected a multidrug-resistant E. coli strain circulating in a wildlife rehabilitation center, reinforcing the importance of adequate hygiene practices when handling and caring for wildlife. We suggest that the relatively high frequency of antimicrobial resistance in the in-care birds and backyard poultry is due primarily to the use of antimicrobials in these animals, and we recommend that the treatment protocols used for these birds be reviewed.
Keywords: Animals
Escherichia coli
Escherichia coli Infections
Virulence Factors
Anti-Bacterial Agents
Carrier State
Drug Resistance, Bacterial
Genetic Variation
Molecular Epidemiology
Rights: Copyright © 2015, American Society for Microbiology. All Rights Reserved.
DOI: 10.1128/AEM.00861-15
Appears in Collections:Animal and Veterinary Sciences publications
Aurora harvest 7

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