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https://hdl.handle.net/2440/9510
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Type: | Journal article |
Title: | Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response |
Author: | Brand, C. Grimbaldeston, M. Gamble, J. Drew, J. Finlay-Jones, J. Hart, P. |
Citation: | Inflammation Research, 2002; 51(5):236-244 |
Publisher: | Birkhauser Verlag Ag |
Issue Date: | 2002 |
ISSN: | 1023-3830 1420-908X |
Statement of Responsibility: | C. Brand, M. A. Grimbaldeston, J. R. Gamble, J. Drew, J. J. Finlay-Jones, P. H. Hart |
Abstract: | <h4>Objective</h4>To examine the anti-inflammatory activities of tea tree oil (TTO) in vivo.<h4>Methods</h4>Mice were sensitized to a chemical hapten, trinitrochlorobenzene, on their ventral skin and 7 days later challenged (or re-exposed) on their dorsal skin with the same hapten.<h4>Results</h4>TTO applied 30 min before or up to 7 h after to the same dorsal site as hapten challenge caused a significant reduction in skin swelling after 24 h. TTO reduced oedema but not the influx of inflammatory cells. This finding was supported by the inability of TTO to suppress TNFalpha-induced E-selectin expression by human umbilical vein endothelial cells. TTO did not suppress irritant- or ultraviolet B-induced oedema.<h4>Conclusion</h4>Topical TTO, specifically the TTO components, terpinen-4-ol and alpha-terpineol can regulate the oedema associated with the efferent phase of a contact hypersensitivity response. |
Keywords: | Endothelium, Vascular Cells, Cultured Skin Animals Mice, Inbred BALB C Humans Mice Dermatitis, Allergic Contact Edema Picryl Chloride Hematoxylin Eosine Yellowish-(YS) Tea Tree Oil Cell Adhesion Molecules Fluorescent Dyes Ultraviolet Rays Coloring Agents Female |
DOI: | 10.1007/PL00000299 |
Published version: | http://dx.doi.org/10.1007/pl00000299 |
Appears in Collections: | Aurora harvest Medicine publications |
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