Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9594
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Accuracy of sampling methods in morphometric studies of human sural nerves |
Author: | Cai, Z. Cash, K. Thompson, P. Blumbergs, P. |
Citation: | Journal of Clinical Neuroscience, 2002; 9(2):181-186 |
Publisher: | Churchill Livingstone |
Issue Date: | 2002 |
ISSN: | 0967-5868 1532-2653 |
Statement of Responsibility: | Z. Cai, K. Cash, P. D. Thompson and P. C. Blumbergs |
Abstract: | The aim of this study was to ascertain the minimum sample required to accurately measure the total number of myelinated fibres, mean myelinated fibre density (MFD), myelinated fibre diameter (Ds) and axonal diameter (Da) in morphometric studies of sural nerve biopsies. Measurements were obtained by sampling a single fascicle or systematic sampling of up to 50% of the total transverse fascicular area of two control and eighteen pathological sural nerves showing varying degrees of demyelination and axonal degeneration. MFD and fibre size were heterogeneous between fascicles in both control and pathological sural nerves, and morphometric results from one fascicle and systematic sampling of up to 50% of the total transverse fascicular area did not accurately represent the whole myelinated fibre population in the sural nerve. For accurate morphometric data it is necessary to quantitate all the myelinated fibres in the sural nerve. |
Keywords: | Nerve Fibers, Myelinated Sural Nerve Humans Statistics, Nonparametric Sampling Studies Adult Aged Middle Aged Female Male |
Description: | Copyright © 2002 Elsevier Science Ltd. All rights reserved. |
DOI: | 10.1054/jocn.2001.1040 |
Published version: | http://dx.doi.org/10.1054/jocn.2001.1040 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.