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Type: Journal article
Title: Accuracy of sampling methods in morphometric studies of human sural nerves
Author: Cai, Z.
Cash, K.
Thompson, P.
Blumbergs, P.
Citation: Journal of Clinical Neuroscience, 2002; 9(2):181-186
Publisher: Churchill Livingstone
Issue Date: 2002
ISSN: 0967-5868
Statement of
Z. Cai, K. Cash, P. D. Thompson and P. C. Blumbergs
Abstract: The aim of this study was to ascertain the minimum sample required to accurately measure the total number of myelinated fibres, mean myelinated fibre density (MFD), myelinated fibre diameter (Ds) and axonal diameter (Da) in morphometric studies of sural nerve biopsies. Measurements were obtained by sampling a single fascicle or systematic sampling of up to 50% of the total transverse fascicular area of two control and eighteen pathological sural nerves showing varying degrees of demyelination and axonal degeneration. MFD and fibre size were heterogeneous between fascicles in both control and pathological sural nerves, and morphometric results from one fascicle and systematic sampling of up to 50% of the total transverse fascicular area did not accurately represent the whole myelinated fibre population in the sural nerve. For accurate morphometric data it is necessary to quantitate all the myelinated fibres in the sural nerve.
Keywords: Nerve Fibers, Myelinated; Sural Nerve; Humans; Statistics, Nonparametric; Sampling Studies; Adult; Aged; Middle Aged; Female; Male
Description: Copyright © 2002 Elsevier Science Ltd. All rights reserved.
RMID: 0020022071
DOI: 10.1054/jocn.2001.1040
Appears in Collections:Medicine publications

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