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Type: Journal article
Title: Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll
Author: Liu, D.
Shaukat, Z.
Saint, R.
Gregory, S.
Citation: Oncotarget, 2015; 6(36):38552-38565
Publisher: Impact Journals
Issue Date: 2015
ISSN: 1949-2553
Statement of
Dawei Liu, Zeeshan Shaukat, Robert B. Saint, and Stephen L. Gregory
Abstract: Chromosomal instability (CIN) is a hallmark of cancer and has been implicated in cancer initiation, progression and the development of resistance to traditional cancer therapy. Here we identify a new property of CIN cells, showing that inducing CIN in proliferating Drosophila larval tissue leads to the activation of innate immune signalling in CIN cells. Manipulation of this immune pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNFα/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of the immune response that is needed for effective elimination of CIN cells.
Keywords: Drosophila; Immune response; Immunity; Immunology Section; TLRs; TNFα; chromosomal instability; innate immune response
Rights: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030037341
DOI: 10.18632/oncotarget.6035
Grant ID:
Appears in Collections:Genetics publications

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