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Type: Journal article
Title: Crosstalk between mTOR complexes
Author: Xie, J.
Proud, C.
Citation: Nature Cell Biology, 2013; 15(11):1263-1265
Publisher: Nature Publishing Group
Issue Date: 2013
ISSN: 1476-4679
Statement of
Jianling Xie and Christopher G. Proud
Abstract: The mTOR protein kinase controls anabolic processes as part of mTOR complexes 1 and 2 (mTORC1 and mTORC2). The two complexes are now shown to be involved in a negative feedback regulatory mechanism, in which mTORC1 stimulation inactivates mTORC2 through the inhibitory phosphorylation of the mTORC2 component Sin1.
Keywords: Multiprotein complexes
Rights: © 2013 Macmillan Publishers Limited. All rights reserved.
RMID: 0030035736
DOI: 10.1038/ncb2877
Appears in Collections:Molecular and Biomedical Science publications

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