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Type: Journal article
Title: Prebiotics: a potential treatment strategy for the chemotherapy-damaged gut?
Author: Wang, H.
Geier, M.
Howarth, G.
Citation: Critical Reviews in Food Science and Nutrition, 2016; 56(6):946-956
Publisher: Taylor & Francis
Issue Date: 2016
ISSN: 1040-8398
Statement of
Hanru Wang, Mark S Geier and Gordon S Howarth
Abstract: Abstract Mucositis, characterized by ulcerative lesions along the alimentary tract, is a common consequence of many chemotherapy regimens. Chemotherapy negatively disrupts the intestinal microbiota, resulting in increased numbers of potentially pathogenic bacteria, such as Clostridia and Enterobacteriaceae, and decreased numbers of "beneficial" bacteria, such as Lactobacilli and Bifidobacteria. Agents capable of restoring homeostasis in the bowel microbiota could therefore be applicable to mucositis. Prebiotics are indigestible compounds, commonly oligosaccharides, which seek to reverse chemotherapy-induced intestinal dysbiosis through selective colonization of the intestinal microbiota by probiotic bacteria. In addition, evidence is emerging that certain prebiotics contribute to nutrient digestibility and absorption, modulate intestinal barrier function through effects on mucin expression, and also modify mucosal immune responses, possibly via inflammasome-mediated processes. This review examines the known mechanisms of prebiotic action and explores their potential to reduce the severity of chemotherapy-induced mucositis in the intestine.
Keywords: Animal models; Chemotherapy; Mucositis; Prebiotics
Rights: Copyright © Taylor and Francis Group, LLC
RMID: 0030012152
DOI: 10.1080/10408398.2012.741082
Appears in Collections:Animal and Veterinary Sciences publications

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