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Type: Journal article
Title: Rhabdomyolysis: A Review
Author: Warren, J.
Blumbergs, P.
Thompson, P.
Citation: Muscle & Nerve, 2002; 25(3):332-347
Publisher: John Wiley & Sons Inc
Issue Date: 2002
ISSN: 0148-639X
Statement of
Jason D. Warren, Peter C. Blumbergs, Philip D. Thompson
Abstract: Rhabdomyolysis, a syndrome of skeletal muscle breakdown with leakage of muscle contents, is frequently accompanied by myoglobinuria, and if sufficiently severe, acute renal failure with potentially life-threatening metabolic derangements may ensue. A diverse spectrum of inherited and acquired disorders affecting muscle membranes, membrane ion channels, and muscle energy supply causes rhabdomyolysis. Common final pathophysiological mechanisms among these causes of rhabdomyolysis include an uncontrolled rise in free intracellular calcium and activation of calcium-dependent proteases, which lead to destruction of myofibrils and lysosomal digestion of muscle fiber contents. Recent advances in molecular genetics and muscle enzyme histochemistry may enable a specific metabolic diagnosis in many patients with idiopathic recurrent rhabdomyolysis.
Keywords: Muscle, Skeletal; Humans; Rhabdomyolysis
Description: Published in Muscle and Nerve, 2002; 25 (3):332-347 at
RMID: 0020022052
DOI: 10.1002/mus.10053
Appears in Collections:Medicine publications

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