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dc.contributor.authorYandell, R.en
dc.contributor.authorSu, Y.en
dc.contributor.authorFraser, R.en
dc.contributor.authorWittert, G.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorMalbert, C.en
dc.contributor.authorShulkes, A.en
dc.contributor.authorVolombello, T.en
dc.contributor.authorChapman, I.en
dc.identifier.citationNeurogastroenterology and Motility, 2002; 14(1):25-33en
dc.descriptionThe definitive version is available at www.blackwell-synergy.comen
dc.description.abstractThe contribution of the pulsatile nature of gastric emptying to small intestinal feedback mechanisms modulating antropyloroduodenal motility and appetite is unknown. On separate days, eight healthy male volunteers (18-34 years) received randomized, single-blind, intraduodenal (ID) infusions of 10% Intralipid (2 kcal min(-1)), either continuously [CID], or in a pulsatile manner [PID] (5 s on/15 s off) and 0.9% saline (control) administered continuously, each at a rate of 1.8 mL min(-1) for 3 h. During each infusion, subjective ratings of appetite were assessed and antropyloroduodenal pressures recorded with a 16-lumen manometric assembly incorporating a pyloric sleeve sensor. Plasma cholecystokinin was measured from blood collected at regular intervals throughout the infusion. At the end of each infusion the manometric assembly was removed, subjects were offered a buffet meal and the energy and macronutrient content of the meal was measured. Both ID lipid infusions stimulated isolated pyloric pressure waves (IPPWs) (P < 0.001) and basal pyloric pressure (P < 0.01) and suppressed antral (P < 0.05) and duodenal (P < 0.05) pressure waves when compared to controls; there was no difference in the effects of CID and PID lipid on antropyloroduodenal pressures. Infusions of lipid significantly increased plasma CCK concentrations (P < 0.05) compared with saline, but concentrations were not different between the two modes of lipid delivery (P > 0.05, CID vs. PID). Both intraduodenal lipid infusions decreased hunger (P < 0.05), increased fullness (P < 0.05) and reduced energy intake (P < 0.05) when compared with controls; again there was no difference between CID and PID lipid. We conclude that at the infusion rate of similar 2 kcal min(-1), the acute effects of intraduodenal lipid on antropyloroduodenal pressures, plasma CCK concentration and appetite are not modified by a pulsatile mode of lipid delivery into the duodenum.en
dc.description.statementofresponsibilityR. Vozzo, Y-C. Su, R. J. Fraser, G. A. Wittert, M. Horowitz, C. H. Malbert,  A. Shulkes, T. Volombello & I. M. Chapmanen
dc.publisherBlackwell Science Ltden
dc.subjectmotility; pylorus; sensationen
dc.titleAntropyloroduodenal, cholecystokinin and feeding responses to pulsatile and non-pulsatile intraduodenal lipid infusionen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidYandell, R. [0000-0003-3801-5593]en
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidMalbert, C. [0000-0002-0665-4545]en
Appears in Collections:Medicine publications

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