Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/97197
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Liu, Y. | - |
dc.contributor.author | DeBoer, K. | - |
dc.contributor.author | de Kretser, D. | - |
dc.contributor.author | O Donnell, L. | - |
dc.contributor.author | O Connor, A. | - |
dc.contributor.author | Merriner, D. | - |
dc.contributor.author | Okuda, H. | - |
dc.contributor.author | Whittle, B. | - |
dc.contributor.author | Jans, D. | - |
dc.contributor.author | Efthymiadis, A. | - |
dc.contributor.author | McLachlan, R. | - |
dc.contributor.author | Ormandy, C. | - |
dc.contributor.author | Goodnow, C. | - |
dc.contributor.author | Jamsai, D. | - |
dc.contributor.author | O Bryan, M. | - |
dc.contributor.editor | Yan, W. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | PLoS Genetics, 2015; 11(3):1-20 | - |
dc.identifier.issn | 1553-7390 | - |
dc.identifier.issn | 1553-7404 | - |
dc.identifier.uri | http://hdl.handle.net/2440/97197 | - |
dc.description.abstract | Male infertility affects at least 5% of reproductive age males. The most common pathology is a complex presentation of decreased sperm output and abnormal sperm shape and motility referred to as oligoasthenoteratospermia (OAT). For the majority of OAT men a precise diagnosis cannot be provided. Here we demonstrate that leucine-rich repeats and guanylate kinase-domain containing isoform 1 (LRGUK-1) is required for multiple aspects of sperm assembly, including acrosome attachment, sperm head shaping and the initiation of the axoneme growth to form the core of the sperm tail. Specifically, LRGUK-1 is required for basal body attachment to the plasma membrane, the appropriate formation of the sub-distal appendages, the extension of axoneme microtubules and for microtubule movement and organisation within the manchette. Manchette dysfunction leads to abnormal sperm head shaping. Several of these functions may be achieved in association with the LRGUK-1 binding partner HOOK2. Collectively, these data establish LRGUK-1 as a major determinant of microtubule structure within the male germ line. | - |
dc.description.statementofresponsibility | Yan Liu, Kathleen DeBoer, David M. de Kretser, Liza O, Donnell, Anne E. O, Connor, D. Jo Merriner, Hidenobu Okuda, Belinda Whittle, David A. Jans, Athina Efthymiadis, Robert I. McLachlan, Christopher J. Ormandy, Chris C. Goodnow, Duangporn Jamsai, Moira K. O, Bryan | - |
dc.language.iso | en | - |
dc.publisher | Public Library of Science | - |
dc.rights | © 2015 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | - |
dc.source.uri | http://dx.doi.org/10.1371/journal.pgen.1005090 | - |
dc.subject | Testis | - |
dc.subject | Spermatozoa | - |
dc.subject | Cell Membrane | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Infertility, Male | - |
dc.subject | Microtubule-Associated Proteins | - |
dc.subject | Protein Isoforms | - |
dc.subject | Sequence Alignment | - |
dc.subject | Spermatogenesis | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Molecular Sequence Data | - |
dc.subject | Male | - |
dc.subject | Basal Bodies | - |
dc.subject | Guanylate Kinases | - |
dc.title | LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1371/journal.pgen.1005090 | - |
dc.relation.grant | NHMRC | - |
dc.relation.grant | ARC | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 7 Medicine publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_97197.pdf | Published version | 15.3 MB | Adobe PDF | View/Open |
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