Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98477
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Type: Journal article
Title: Prenatal exposures and anti-müllerian hormone in female adolescents: the Avon Longitudinal Study of Parents and Children
Other Titles: Prenatal exposures and anti-mullerian hormone in female adolescents: the Avon Longitudinal Study of Parents and Children
Author: Fraser, A.
McNally, W.
Sattar, N.
Anderson, E.
Lashen, H.
Fleming, R.
Lawlor, D.
Nelson, S.
Citation: American Journal of Epidemiology, 2013; 178(9):1414-1423
Publisher: Oxford University Press
Issue Date: 2013
ISSN: 0002-9262
1476-6256
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Responsibility: 
Abigail Fraser, William McNally, Naveed Sattar, Emma L. Anderson, Hany Lashen, Richard Fleming, Debbie A. Lawlor, and Scott M. Nelson
Abstract: Given that the primordial ovarian follicular pool is established in utero, it may be influenced by parental characteristics and the intrauterine environment. Anti-Müllerian hormone (AMH) levels are increasingly recognized as a biomarker of ovarian reserve in females in adulthood and adolescence. We examined and compared associations of maternal and paternal prenatal exposures with AMH levels in adolescent (mean age, 15.4 years) female offspring (n = 1,399) using data from the Avon Longitudinal Study of Parents and Children, a United Kingdom birth cohort study that originated in 1991 and is still ongoing (data are from 1991-2008). The median AMH level was 3.67 ng/mL (interquartile range: 2.46-5.57). Paternal but not maternal smoking prior to and during pregnancy were inversely associated with AMH levels. No or irregular maternal menstrual cycles before pregnancy were associated with higher AMH levels in daughter during adolescence. High maternal gestational weight gain (top fifth versus the rest of the distribution) was associated with lower AMH levels in daughters. Parental age, body mass index, and alcohol intake during pregnancy, child's birth weight, and maternal parity and time to conception were not associated with daughters' AMH levels. Our results suggest that some parental preconceptual characteristics and environmental exposures while the child is in utero may influence the long-term ovarian development and function in female offspring.
Keywords: anti-Müllerian hormone; maternal-paternal comparisons; prenatal risk factors
Description: First published online: September 5, 2013
Rights: © The Author 2013. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0030042764
DOI: 10.1093/aje/kwt137
Appears in Collections:Medicine publications

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