Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98478
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Type: Journal article
Title: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Author: Horikoshi, M.
Yaghootkar, H.
Mook-Kanamori, D.
Sovio, U.
Taal, H.
Hennig, B.
Bradfield, J.
St Pourcain, B.
Evans, D.
Charoen, P.
Kaakinen, M.
Cousminer, D.
Lehtimäki, T.
Kreiner-Møller, E.
Warrington, N.
Bustamante, M.
Feenstra, B.
Berry, D.
Thiering, E.
Pfab, T.
et al.
Citation: Nature Genetics, 2013; 45(1):76-82
Publisher: Nature Publishing Group
Issue Date: 2013
ISSN: 1061-4036
1546-1718
Statement of
Responsibility: 
Momoko Horikoshi … Debbie A Lawlor ... et al. for the Early Growth Genetics (EGG) Consortium
Abstract: Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Keywords: Genetic Linkage
Description: Published online 02 December 2012
Rights: © 2013 Nature America, Inc. All rights reserved.
RMID: 0030042794
DOI: 10.1038/ng.2477
Grant ID: http://purl.org/au-research/grants/nhmrc/403981
http://purl.org/au-research/grants/nhmrc/003209
Appears in Collections:Medicine publications

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