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https://hdl.handle.net/2440/98478
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Type: | Journal article |
Title: | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism |
Author: | Horikoshi, M. Yaghootkar, H. Mook-Kanamori, D. Sovio, U. Taal, H. Hennig, B. Bradfield, J. St Pourcain, B. Evans, D. Charoen, P. Kaakinen, M. Cousminer, D. Lehtimäki, T. Kreiner-Møller, E. Warrington, N. Bustamante, M. Feenstra, B. Berry, D. Thiering, E. Pfab, T. et al. |
Citation: | Nature Genetics, 2013; 45(1):76-82 |
Publisher: | Nature Publishing Group |
Issue Date: | 2013 |
ISSN: | 1061-4036 1546-1718 |
Statement of Responsibility: | Momoko Horikoshi … Debbie A Lawlor ... et al. for the Early Growth Genetics (EGG) Consortium |
Abstract: | Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. |
Keywords: | Genetic Linkage |
Description: | Published online 02 December 2012 |
Rights: | © 2013 Nature America, Inc. All rights reserved. |
DOI: | 10.1038/ng.2477 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/403981 http://purl.org/au-research/grants/nhmrc/003209 |
Published version: | http://dx.doi.org/10.1038/ng.2477 |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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