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https://hdl.handle.net/2440/98478
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dc.contributor.author | Horikoshi, M. | - |
dc.contributor.author | Yaghootkar, H. | - |
dc.contributor.author | Mook-Kanamori, D. | - |
dc.contributor.author | Sovio, U. | - |
dc.contributor.author | Taal, H. | - |
dc.contributor.author | Hennig, B. | - |
dc.contributor.author | Bradfield, J. | - |
dc.contributor.author | St Pourcain, B. | - |
dc.contributor.author | Evans, D. | - |
dc.contributor.author | Charoen, P. | - |
dc.contributor.author | Kaakinen, M. | - |
dc.contributor.author | Cousminer, D. | - |
dc.contributor.author | Lehtimäki, T. | - |
dc.contributor.author | Kreiner-Møller, E. | - |
dc.contributor.author | Warrington, N. | - |
dc.contributor.author | Bustamante, M. | - |
dc.contributor.author | Feenstra, B. | - |
dc.contributor.author | Berry, D. | - |
dc.contributor.author | Thiering, E. | - |
dc.contributor.author | Pfab, T. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Nature Genetics, 2013; 45(1):76-82 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.issn | 1546-1718 | - |
dc.identifier.uri | http://hdl.handle.net/2440/98478 | - |
dc.description | Published online 02 December 2012 | - |
dc.description.abstract | Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism. | - |
dc.description.statementofresponsibility | Momoko Horikoshi … Debbie A Lawlor ... et al. for the Early Growth Genetics (EGG) Consortium | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.rights | © 2013 Nature America, Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1038/ng.2477 | - |
dc.subject | Genetic Linkage | - |
dc.title | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/ng.2477 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/403981 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/003209 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
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