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Type: Journal article
Title: Cohort profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Author: Fraser, A.
Macdonald-wallis, C.
Tilling, K.
Boyd, A.
Golding, J.
Smith, G.
Henderson, J.
Macleod, J.
Molloy, L.
Ness, A.
Ring, S.
Nelson, S.
Lawlor, D.
Citation: International Journal of Epidemiology, 2013; 42(1):97-110
Publisher: Oxford University Press
Issue Date: 2013
ISSN: 0300-5771
Statement of
Abigail Fraser, Corrie Macdonald-Wallis, Kate Tilling, Andy Boyd, Jean Golding, George Davey Smith, John Henderson, John Macleod, Lynn Molloy, Andy Ness, Susan Ring, Scott M Nelson and Debbie A Lawlor
Abstract: Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13761 women (contributing 13867 pregnancies) were recruited. These women have been followed over the last 19-22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17-18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on >10000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile.
Keywords: Humans
Description: First published online: April 16, 2012
Rights: © The Author 2012; all rights reserved.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Published by Oxford University Press on behalf of the International Epidemiological Association
RMID: 0030042806
DOI: 10.1093/ije/dys066
Appears in Collections:Medicine publications

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