Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98663
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Type: Journal article
Title: Associations of blood pressure in pregnancy with offspring blood pressure trajectories during childhood and adolescence: findings from a prospective study
Author: Staley, J.
Bradley, J.
Silverwood, R.
Howe, L.
Tilling, K.
Lawlor, D.
Macdonald-Wallis, C.
Citation: Journal of the American Heart Association, 2015; 4(5):e001422-1-e001422-12
Publisher: American Heart Association
Issue Date: 2015
ISSN: 2047-9980
2047-9980
Statement of
Responsibility: 
James R. Staley, John Bradley, Richard J. Silverwood, Laura D. Howe, Kate Tilling, Debbie A. Lawlor, Corrie Macdonald-Wallis
Abstract: BACKGROUND Hypertensive disorders of pregnancy are related to higher offspring blood pressure (BP), but it is not known whether this association strengthens or weakens as BP changes across childhood. Our aim was to assess the associations of hypertensive disorders of pregnancy and maternal BP changes during pregnancy with trajectories of offspring BP from age 7 to 18 years. METHODS AND RESULTS In a large UK cohort of maternal–offspring pairs (N=6619), we used routine antenatal BP measurements to derive hypertensive disorders of pregnancy and maternal BP trajectories. These were related to offspring BP trajectories, obtained from research clinic assessments, using linear spline random‐effects models. After adjusting for maternal and offspring variables, including body mass index, offspring of women who had existing hypertension, gestational hypertension, or preeclampsia during pregnancy had on average higher BP at age 7 years compared to offspring of normotensive pregnancies (mean difference [95%CI] in systolic BP: 1.67 mm Hg [0.48, 2.86], 1.98 mm Hg [1.32, 2.65], and 1.22 mm Hg [−0.52, 2.97], respectively). These differences were consistent across childhood to age 18 years, as the patterns of BP change did not differ between offspring of hypertensive pregnancies and normotensive pregnancies. Maternal BP at 8 weeks’ gestation was also positively associated with offspring BP in childhood and adolescence, but changes in BP across pregnancy were not strongly associated. CONCLUSIONS The differences in BP between offspring of hypertensive pregnancies and offspring of normotensive pregnancies remain consistent across childhood and adolescence. These associations appear to be most contributed to by higher maternal BP in early pregnancy rather than by pregnancy‐related BP changes.
Keywords: ALSPAC; blood pressure; change; childhood; gestational hypertension; preeclampsia; pregnancy
Rights: © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
RMID: 0030041743
DOI: 10.1161/JAHA.114.001422
Appears in Collections:Medicine publications

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