Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98898
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Type: Journal article
Title: Hypertensive disorders of pregnancy, respiratory outcomes and atopy in childhood
Author: Shaheen, S.
Macdonald-Wallis, C.
Lawlor, D.
Henderson, A.
Citation: European Respiratory Journal, 2016; 47(1):156-165
Publisher: European Respiratory Society
Issue Date: 2016
ISSN: 0903-1936
1399-3003
Statement of
Responsibility: 
Seif O. Shaheen, Corrie Macdonald-Wallis, Debbie A. Lawlor and A. John Henderson
Abstract: Few epidemiological studies have investigated the role of hypertensive disorders of pregnancy in the aetiology of childhood respiratory and atopic outcomes.In the Avon Longitudinal Study of Parents and Children we examined associations of maternal gestational hypertension, hypertension before pregnancy and pre-eclampsia with wheezing at 18 months, wheezing and asthma at 7 years and lung function at 8-9 years, after controlling for potential confounders (n=5322-8734, depending on outcome).Gestational hypertension was not associated with any of the outcomes. There was weak evidence for a positive association between pre-eclampsia and early wheezing (adjusted OR 1.31, 95% CI 0.94-1.82, compared to normotensive pregnancies) and for negative associations between pre-eclampsia and forced expiratory volume in 1 s (adjusted mean difference in sd score -0.14, 95% CI -0.33-0.06) and maximal mid-expiratory flow (-0.15, 95% CI -0.34-0.04). Hypertension before pregnancy was positively associated with wheezing (OR 1.63, 95% CI 1.16-2.31) and asthma (OR 1.34, 95% CI 1.00-1.79).Gestational hypertension is unlikely to be a risk factor for childhood respiratory disorders; hypertension before pregnancy may be a risk factor for childhood wheezing and asthma, but this finding needs replication. Larger studies are needed to confirm whether pre-eclampsia is associated with impaired childhood lung function.
Keywords: Humans; Asthma; Hypertension, Pregnancy-Induced; Pre-Eclampsia; Pregnancy Complications, Cardiovascular; Prenatal Exposure Delayed Effects; Hypertension; Hypersensitivity, Immediate; Respiratory Sounds; Forced Expiratory Volume; Risk Factors; Longitudinal Studies; Pregnancy; Child; Infant; Female; Male; United Kingdom
Description: Published 1 January 2016
Rights: Copyright ©ERS 2016
RMID: 0030042391
DOI: 10.1183/13993003.00643-2015
Appears in Collections:Medicine publications

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