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|Title:||Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort|
|Citation:||British Journal of Psychiatry, 2014; 204(1):40-45|
|Publisher:||Royal College of Psychiatrists|
|Carol A. Mathews, Jeremiah M. Scharf, Laura L. Miller, Corrie Macdonald-Wallis, Debbie A. Lawlor, Yoav Ben-Shlomo|
|Abstract:||Tourette syndrome and chronic tic disorder are heritable but aetiologically complex. Although environment plays a role in their development, existing studies of non-genetic risk factors are inconsistent.To examine the association between pre- and perinatal exposures and Tourette syndrome/chronic tic disorder in the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective longitudinal pre-birth cohort.Relationships between exposures and Tourette syndrome/chronic tic disorder were examined in 6090 children using logistic regression.Maternal alcohol and cannabis use, inadequate maternal weight gain and parity were associated with Tourette syndrome or Tourette syndrome/chronic tic disorder. Other previously reported exposures, including birth weight and prenatal maternal smoking, were not associated with Tourette syndrome/chronic tic disorder.This study supports previously reported relationships between Tourette syndrome/chronic tic disorder and prenatal alcohol exposure, and identifies additional previously unexplored potential prenatal risk factors.|
|Keywords:||Tourette Syndrome; Tic Disorders|
|Rights:||© The Royal College of Psychiatrists|
|Appears in Collections:||Medicine publications|
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