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Type: Journal article
Title: Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort
Author: Mathews, C.
Scharf, J.
Miller, L.
Macdonald-Wallis, C.
Lawlor, D.
Ben-Shlomo, Y.
Citation: British Journal of Psychiatry, 2014; 204(1):40-45
Publisher: Royal College of Psychiatrists
Issue Date: 2014
ISSN: 0007-1250
Statement of
Carol A. Mathews, Jeremiah M. Scharf, Laura L. Miller, Corrie Macdonald-Wallis, Debbie A. Lawlor, Yoav Ben-Shlomo
Abstract: Tourette syndrome and chronic tic disorder are heritable but aetiologically complex. Although environment plays a role in their development, existing studies of non-genetic risk factors are inconsistent.To examine the association between pre- and perinatal exposures and Tourette syndrome/chronic tic disorder in the Avon Longitudinal Study of Parents and Children (ALSPAC) prospective longitudinal pre-birth cohort.Relationships between exposures and Tourette syndrome/chronic tic disorder were examined in 6090 children using logistic regression.Maternal alcohol and cannabis use, inadequate maternal weight gain and parity were associated with Tourette syndrome or Tourette syndrome/chronic tic disorder. Other previously reported exposures, including birth weight and prenatal maternal smoking, were not associated with Tourette syndrome/chronic tic disorder.This study supports previously reported relationships between Tourette syndrome/chronic tic disorder and prenatal alcohol exposure, and identifies additional previously unexplored potential prenatal risk factors.
Keywords: Tourette Syndrome; Tic Disorders
Rights: © The Royal College of Psychiatrists
RMID: 0030042736
DOI: 10.1192/bjp.bp.112.125468
Appears in Collections:Medicine publications

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