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|Title:||Quantitative interpretation of FDG PET/CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis|
|Citation:||Journal of Nuclear Cardiology, 2014; 21(5):925-939|
|Azadeh Ahmadian, Ashley Brogan, Jeffrey Berman, Aaron L. Sverdlov, Gustavo Mercier, Michael Mazzini, Praveen Govender, Frederick L. Ruberg, and Edward J. Mille|
|Abstract:||Background: FDG PET/CT with myocardial perfusion imaging is a useful method for evaluating cardiac sarcoidosis (CS), but interpretation is not standardized. We developed a method for quantification of cardiac FDG PET/CT and evaluated its relationship to conventional interpretation, perfusion defects, clinical events, and immunosuppressive treatment. Methods and Results: FDG PET/CT with MPI studies performed for CS (n = 38) were retrospectively compared to negative control studies acquired for oncologic indications (n = 10). Quantitative measures of FDG volume-intensity (Cardiac Metabolic Activity, CMA) was performed using standardized uptake values (SUVs). CMA (477.7 ± 909 vs 0.55 ± 2.1 vs 0.3 ± 0.3 g glucose, P = .02) was significantly greater in visually FDG-positive studies compared to visually negative and oncologic negative studies. Among patients with CS, CMA was greater in studies with an EF < 50% (760.3 ± 1,148 vs 87.4 ± 161 g glucose, P = .03) and preceding an adverse clinical event (1,095 ± 1,253 vs 73 ± 144 g glucose, P = .006). CMA was the only independent predictor of events by multivariate analysis. In patients with repeat examinations (n 5 7), CMA decreased with prednisone treatment in 5 of 6 patients. Conclusions: Quantification of FDG uptake in CS correlates with lower EFs, clinical events, and immunosuppression treatment.|
|Keywords:||Metabolism: PET; PET/CT imaging; fluorodeoxyglucose (FDG)|
|Rights:||Copyright © 2014 American Society of Nuclear Cardiology.|
|Appears in Collections:||Medicine publications|
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