Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/99422
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dc.contributor.authorShaukat, Z.en
dc.contributor.authorLiu, D.en
dc.contributor.authorGregory, S.en
dc.date.issued2015en
dc.identifier.citationMediators of Inflammation, 2015; 2015:369286-1-369286-7en
dc.identifier.issn0962-9351en
dc.identifier.issn1466-1861en
dc.identifier.urihttp://hdl.handle.net/2440/99422-
dc.description.abstractThe study of immune responses in Drosophila has already yielded significant results with impacts on our understanding of vertebrate immunity, such as the characterization of the Toll receptor. Several recent papers have focused on the humoral response to damage signals rather than pathogens, particularly damage signals from tumour-like tissues generated by loss of cell polarity or chromosomal instability. Both the triggers that generate this sterile inflammation and the systemic and local effects of it are only just beginning to be characterized in Drosophila. Here we review the molecular mechanisms that are known that give rise to the recruitment of Drosophila phagocytes, called hemocytes, as well as the signals, such as TNFα, that stimulated hemocytes emit at sites of perceived damage. The signalling consequences of inflammation, such as the activation of JNK, and the potential for modifying this response are also discussed.en
dc.description.statementofresponsibilityZeeshan Shaukat, Dawei Liu, and Stephen Gregoryen
dc.language.isoenen
dc.publisherHindawi Publishing Corporationen
dc.rightsCopyright © 2015 Zeeshan Shaukat et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectInflammationen
dc.titleSterile inflammation in drosophilaen
dc.typeJournal articleen
dc.identifier.rmid0030030260en
dc.identifier.doi10.1155/2015/369286en
dc.identifier.pubid185416-
pubs.library.collectionGenetics publicationsen
pubs.library.teamDS03en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGregory, S. [0000-0002-0046-5815]en
Appears in Collections:Genetics publications

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