Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: A chromosome conformation capture ordered sequence of the barley genome
Author: Mascher, M.
Gundlach, H.
Himmelbach, A.
Beier, S.
Twardziok, S.
Wicker, T.
Radchuk, V.
Dockter, C.
Hedley, P.
Russell, J.
Bayer, M.
Ramsay, L.
Liu, H.
Haberer, G.
Zhang, X.
Zhang, Q.
Barrero, R.
Li, L.
Taudien, S.
Groth, M.
et al.
Citation: Nature, 2017; 544(7651):427-433
Publisher: Nature Publishing Group
Issue Date: 2017
ISSN: 0028-0836
Statement of
Martin Mascher, Heidrun Gundlach, Axel Himmelbach, Sebastian Beier … Peter Langridge … Robbie Waugh … et al.
Abstract: Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually devoid of meiotic recombination. Here we present a high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome conformation capture mapping to derive the linear order of sequences across the pericentromeric space and to investigate the spatial organization of chromatin in the nucleus at megabase resolution. The composition of genes and repetitive elements differs between distal and proximal regions. Gene family analyses reveal lineage-specific duplications of genes involved in the transport of nutrients to developing seeds and the mobilization of carbohydrates in grains. We demonstrate the importance of the barley reference sequence for breeding by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion.
Keywords: Chromosomes, Artificial, Bacterial
Chromosomes, Plant
Cell Nucleus
Chromosome Mapping
Repetitive Sequences, Nucleic Acid
Genome, Plant
Genetic Variation
Rights: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit
DOI: 10.1038/nature22043
Appears in Collections:Agriculture, Food and Wine publications
Aurora harvest 3

Files in This Item:
File Description SizeFormat 
hdl_106563.pdfPublished version11.16 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.