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https://hdl.handle.net/2440/110935
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Type: | Journal article |
Title: | Plasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase |
Author: | Phillips, P. Sasadeus, J. Hodsman, G. Horowitz, J. Saltups, A. Johnston, C. |
Citation: | Heart, 1989; 61(2):139-143 |
Publisher: | BMJ Publishing Group |
Issue Date: | 1989 |
ISSN: | 0007-0769 1355-6037 |
Statement of Responsibility: | P A Phillips, J Sasadeus, G P Hodsman, J Horowitz, A Saltups, C I Johnston |
Abstract: | Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase. |
Keywords: | Atrial Natriuretic Factor |
Description: | Published Online First: 01 Sep 1989. |
Rights: | Copyright status unknown |
DOI: | 10.1136/hrt.61.2.139 |
Published version: | http://dx.doi.org/10.1136/hrt.61.2.139 |
Appears in Collections: | Aurora harvest 3 Public Health publications |
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