Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/111064
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dc.contributor.authorCildir, G.en
dc.contributor.authorPant, H.en
dc.contributor.authorLopez, A.en
dc.contributor.authorTergaonkar, V.en
dc.date.issued2017en
dc.identifier.citationJournal of Experimental Medicine, 2017; 214(9):2491-2506en
dc.identifier.issn0022-1007en
dc.identifier.issn1540-9538en
dc.identifier.urihttp://hdl.handle.net/2440/111064-
dc.description.abstractMast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.en
dc.description.statementofresponsibilityGökhan Cildir, Harshita Pant, Angel F. Lopez, Vinay Tergaonkaren
dc.language.isoenen
dc.publisherRockefeller University Pressen
dc.rights© 2017 Cildir et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).en
dc.subjectGene Expression Regulationen
dc.titleThe transcriptional program, functional heterogeneity, and clinical targeting of mast cellsen
dc.typeJournal articleen
dc.identifier.rmid0030078735en
dc.identifier.doi10.1084/jem.20170910en
dc.identifier.pubid367267-
pubs.library.collectionGenetics publicationsen
pubs.library.teamDS10en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLopez, A. [0000-0001-7430-0135]en
Appears in Collections:Genetics publications

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