Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/111064
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Type: | Journal article |
Title: | The transcriptional program, functional heterogeneity, and clinical targeting of mast cells |
Author: | Cildir, G. Pant, H. Lopez, A. Tergaonkar, V. |
Citation: | Journal of Experimental Medicine, 2017; 214(9):2491-2506 |
Publisher: | Rockefeller University Press |
Issue Date: | 2017 |
ISSN: | 0022-1007 1540-9538 |
Statement of Responsibility: | Gökhan Cildir, Harshita Pant, Angel F. Lopez, Vinay Tergaonkar |
Abstract: | Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases. |
Keywords: | Gene Expression Regulation |
Rights: | © 2017 Cildir et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
DOI: | 10.1084/jem.20170910 |
Published version: | http://dx.doi.org/10.1084/jem.20170910 |
Appears in Collections: | Aurora harvest 8 Genetics publications |
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hdl_111064.pdf | Published Version | 2.22 MB | Adobe PDF | View/Open |
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